Detailed information of TA system TA052792

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): prlF-yhaV (relBE)/YhaV-PrlF
• Location: 2174868..2175709
• Replicon: chromosome
• Accession: NZ_CP010537
• Organism: Cupriavidus basilensis strain 4G11

Toxin (Protein)

• Gene name: yhaV
• Uniprot ID: -
• Locus tag: RR42_RS30300
• Protein ID: WP_043355464.1
• Coordinates: 2174868..2175383 (-)
• Length: 172 a.a.

Antitoxin (Protein)

• Gene name: prlF
• Uniprot ID: A0A0C4YD49
• Locus tag: RR42_RS30305
• Protein ID: WP_043355466.1
• Coordinates: 2175380..2175709 (-)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RR42_RS30275	2170284..2170970	+	687	WP_043355453.1	hydrolase	-
RR42_RS30280	2171188..2172009	+	822	WP_043358219.1	alpha/beta hydrolase	-
RR42_RS30285	2172164..2174014	+	1851	WP_043358220.1	amidohydrolase	-
RR42_RS30290	2174031..2174471	+	441	WP_043355456.1	DoxX family protein	-
RR42_RS30295	2174540..2174836	+	297	WP_043355459.1	XapX domain-containing protein	-
RR42_RS30300	2174868..2175383	-	516	WP_043355464.1	type II toxin-antitoxin system YhaV family toxin	Toxin
RR42_RS30305	2175380..2175709	-	330	WP_043355466.1	type II toxin-antitoxin system PrlF family antitoxin	Antitoxin
RR42_RS30310	2176174..2176602	+	429	WP_043358221.1	CBS domain-containing protein	-
RR42_RS30315	2176666..2177097	-	432	WP_043355467.1	HEAT repeat domain-containing protein	-
RR42_RS30320	2177066..2178043	-	978	WP_043355470.1	HEAT repeat domain-containing protein	-
RR42_RS30325	2178135..2178701	-	567	WP_043355473.1	FMN reductase	-
RR42_RS30330	2179303..2179917	+	615	WP_043355475.1	phosphatase PAP2 family protein	-
RR42_RS30335	2179968..2180582	+	615	WP_043355477.1	ATP-binding cassette domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin endonuclease, YhaV (16-152)

Antitoxin

• PrlF antitoxin (8-107)

Sequences

Toxin

Protein

• Length: 172 a.a.
• Molecular weight: 19743.43 Da
• Isoelectric Point: 9.9356

>T52792 WP_043355464.1 NZ_CP010537:c2175383-2174868 [Cupriavidus basilensis]
MSASQPAPLIINGWTVFAHPLFLAQLEGLTRQVEALKQRDPTGYVKKNASKRLAAITRLAFEVIAQDPARPEYRQRGTLG
DDHKHWFRAKFFQQYRLFFRYHAQSRVIVFAWVNDEDTKRACESSDDAYRVFRKMLESGHPPDDWNQLLAEARAEDLRLQ
RMAAGAAQVQP

Nucleotide

• Length: 516 bp

>T52792 NZ_CP010537:c2175383-2174868 [Cupriavidus basilensis]
ATGAGCGCGAGTCAGCCTGCGCCTTTGATCATCAACGGTTGGACTGTTTTCGCCCATCCGCTGTTTCTCGCTCAACTTGA
GGGGCTGACCCGACAAGTCGAAGCGCTCAAGCAAAGAGACCCAACCGGCTACGTGAAGAAGAACGCCAGCAAACGGCTGG
CGGCGATCACCAGGCTGGCGTTCGAGGTGATCGCGCAGGACCCGGCACGGCCGGAATACCGGCAGCGCGGCACTCTCGGC
GACGATCACAAACATTGGTTCCGGGCCAAGTTCTTTCAACAGTACCGGCTGTTCTTTCGCTACCACGCGCAAAGCAGGGT
AATCGTATTTGCCTGGGTCAACGATGAAGACACCAAGCGCGCCTGCGAGAGCAGCGACGACGCCTACCGCGTATTCCGCA
AGATGCTGGAAAGCGGCCACCCTCCAGACGACTGGAATCAGCTACTGGCCGAGGCGCGCGCGGAAGACCTGCGCTTGCAG
CGGATGGCTGCGGGAGCAGCGCAGGTACAGCCTTGA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 11989.50 Da
• Isoelectric Point: 4.5849

>AT52792 WP_043355466.1 NZ_CP010537:c2175709-2175380 [Cupriavidus basilensis]
MAATLEVESTLTDRYQTTVPETVRRALRLGKRDKIHYTIRPGGEVVLTRAEAPEGDDPVLGNFLSFLVRDIASHPERLQA
VDASFVRRIQSLVGGIEVDLDAALSADDE

Nucleotide

• Length: 330 bp

>AT52792 NZ_CP010537:c2175709-2175380 [Cupriavidus basilensis]
ATGGCTGCCACCCTTGAAGTCGAATCCACGCTGACCGACCGCTATCAGACCACCGTGCCGGAAACCGTGCGCCGCGCCCT
GCGGCTGGGCAAGCGCGACAAGATCCACTACACGATCCGCCCCGGCGGCGAAGTCGTGCTGACGCGCGCCGAGGCCCCCG
AGGGGGACGATCCGGTGCTGGGCAACTTCCTGAGTTTCCTGGTCCGCGACATCGCCAGCCATCCAGAGCGCCTGCAGGCC
GTCGATGCCAGTTTCGTGCGGCGCATCCAGTCGCTGGTCGGTGGCATCGAAGTGGATCTTGATGCCGCCCTTTCGGCTGA
CGATGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0C4YD49