Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2540755..2540939 Replicon chromosome
Accession NZ_CP010526
Organism Staphylococcus aureus subsp. aureus ST772-MRSA-V strain DAR4145

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag RU53_RS15865 Protein ID WP_000482647.1
Coordinates 2540832..2540939 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2540755..2540815 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RU53_RS15850 2536206..2536373 - 168 Protein_2449 hypothetical protein -
RU53_RS12920 2536604..2538337 - 1734 WP_000486506.1 ABC transporter ATP-binding protein/permease -
RU53_RS12925 2538362..2540125 - 1764 WP_001064814.1 ABC transporter ATP-binding protein/permease -
- 2540755..2540815 + 61 - - Antitoxin
RU53_RS15865 2540832..2540939 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
RU53_RS12940 2541073..2541459 - 387 WP_000779360.1 flippase GtxA -
RU53_RS12945 2541717..2542859 + 1143 WP_001837638.1 glycerate kinase -
RU53_RS12950 2542919..2543578 + 660 WP_000831301.1 membrane protein -
RU53_RS12955 2543760..2544971 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
RU53_RS12960 2545094..2545567 - 474 WP_000456486.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T52784 WP_000482647.1 NZ_CP010526:c2540939-2540832 [Staphylococcus aureus subsp. aureus ST772-MRSA-V]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T52784 NZ_CP010526:c2540939-2540832 [Staphylococcus aureus subsp. aureus ST772-MRSA-V]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT52784 NZ_CP010526:2540755-2540815 [Staphylococcus aureus subsp. aureus ST772-MRSA-V]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References