Detailed information of TA system TA052768

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): holin-SprF1/-
• Location: 1604048..1604574
• Replicon: chromosome
• Accession: NZ_CP010526
• Organism: Staphylococcus aureus subsp. aureus ST772-MRSA-V strain DAR4145

Toxin (Protein)

• Gene name: holin
• Uniprot ID: -
• Locus tag: RU53_RS07855
• Protein ID: WP_000992284.1
• Coordinates: 1604048..1604350 (-)
• Length: 101 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1604399..1604574 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RU53_RS07835	1599842..1600027	-	186	WP_000470336.1	hypothetical protein	-
RU53_RS07840	1600276..1601259	-	984	WP_024937002.1	Panton-Valentine bi-component leukocidin subunit F	-
RU53_RS07845	1601255..1602193	-	939	WP_000239544.1	Panton-Valentine bi-component leukocidin subunit S	-
RU53_RS07850	1602583..1604037	-	1455	WP_000909197.1	N-acetylmuramoyl-L-alanine amidase	-
RU53_RS07855	1604048..1604350	-	303	WP_000992284.1	phage holin	Toxin
-	1604399..1604574	+	176	-	-	Antitoxin
RU53_RS07865	1604517..1604738	-	222	WP_073391028.1	putative holin-like toxin	-
RU53_RS07870	1604847..1605620	-	774	WP_000750407.1	staphylococcal enterotoxin type A	-
RU53_RS07875	1606041..1606415	-	375	WP_000340977.1	hypothetical protein	-
RU53_RS07880	1606471..1606758	-	288	WP_001262620.1	hypothetical protein	-
RU53_RS15300	1606804..1606956	-	153	WP_001000058.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukF-PV / lukS-PV / sea / gnd	1596900..1666620	69720

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Holin (2-68)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11159.91 Da
• Isoelectric Point: 9.8680

>T52768 WP_000992284.1 NZ_CP010526:c1604350-1604048 [Staphylococcus aureus subsp. aureus ST772-MRSA-V]
MNAKVITRYIVLILALVNQFLANKGISPIPVDEESVSSIILTVVALYTTYKDNPTSQEGKWANQKLKKYKAENKYRKATG
QAPIKEVMTPTNMNDTNDLG

Nucleotide

• Length: 303 bp

>T52768 NZ_CP010526:c1604350-1604048 [Staphylococcus aureus subsp. aureus ST772-MRSA-V]
ATGAATGCAAAAGTAATAACAAGATATATAGTATTAATTTTAGCGTTAGTCAATCAGTTTTTAGCGAATAAAGGTATAAG
TCCGATACCAGTAGATGAAGAAAGTGTTTCATCGATTATCTTAACAGTTGTTGCTTTATATACTACATATAAAGATAATC
CAACATCTCAAGAAGGTAAATGGGCAAATCAAAAGCTAAAGAAATATAAAGCTGAAAACAAGTATAGAAAAGCAACAGGG
CAAGCGCCAATTAAAGAAGTAATGACACCTACGAATATGAACGACACAAATGATTTAGGGTAG

Antitoxin

Nucleotide

• Length: 176 bp

>AT52768 NZ_CP010526:1604399-1604574 [Staphylococcus aureus subsp. aureus ST772-MRSA-V]
ATTTGATATTTATATTATGGTGTGTTAATTTATATTTAGAAAAAGGGCAACATACGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAACCAAAGTTAGCGAT
GGTTATTTTTTTATTG

Structures

Antitoxin