Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3904157..3904850 Replicon chromosome
Accession NZ_CP010443
Organism Escherichia coli K-12 strain K-12 MG1655

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag SH04_RS19260 Protein ID WP_000415584.1
Coordinates 3904554..3904850 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag SH04_RS19255 Protein ID WP_000650107.1
Coordinates 3904157..3904552 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SH04_RS19245 3900021..3902279 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
SH04_RS19250 3902417..3904024 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
SH04_RS19255 3904157..3904552 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
SH04_RS19260 3904554..3904850 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
SH04_RS19265 3905055..3905537 - 483 WP_000183505.1 transcriptional regulator -
SH04_RS19270 3905590..3905982 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
SH04_RS19275 3906134..3906793 + 660 WP_001221495.1 two-component system response regulator QseB -
SH04_RS19280 3906790..3908139 + 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
SH04_RS19285 3908185..3908517 - 333 WP_000917684.1 DUF2645 family protein -
SH04_RS19290 3908836..3909417 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
SH04_RS19295 3909448..3909762 + 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T52646 WP_000415584.1 NZ_CP010443:c3904850-3904554 [Escherichia coli K-12]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T52646 NZ_CP010443:c3904850-3904554 [Escherichia coli K-12]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT52646 WP_000650107.1 NZ_CP010443:c3904552-3904157 [Escherichia coli K-12]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT52646 NZ_CP010443:c3904552-3904157 [Escherichia coli K-12]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References