52360

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2511900..2512423 Replicon chromosome
Accession NZ_CP010402
Organism Staphylococcus aureus strain GR2

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0E1VXK4
Locus tag RT44_RS12785 Protein ID WP_000074045.1
Coordinates 2511900..2512166 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0E1VMY7
Locus tag RT44_RS12790 Protein ID WP_000587619.1
Coordinates 2512166..2512423 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RT44_RS12765 2507206..2508393 - 1188 WP_000026189.1 MFS transporter -
RT44_RS12770 2508789..2509565 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
RT44_RS12775 2509558..2510220 - 663 WP_000923523.1 ATP-binding cassette domain-containing protein -
RT44_RS12780 2510468..2511544 - 1077 WP_001076673.1 M42 family metallopeptidase -
RT44_RS12785 2511900..2512166 - 267 WP_000074045.1 Txe/YoeB family addiction module toxin Toxin
RT44_RS12790 2512166..2512423 - 258 WP_000587619.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
RT44_RS12800 2512782..2513237 + 456 WP_000732090.1 YehR family lipoprotein -
RT44_RS12805 2513405..2514982 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
RT44_RS12810 2515177..2515926 + 750 WP_000072440.1 hypothetical protein -
RT44_RS12815 2516157..2517350 - 1194 WP_000675402.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10632.36 Da        Isoelectric Point: 10.2519

>T52360 WP_000074045.1 NZ_CP010402:c2512166-2511900 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHPYLKKTFIEIVETLKNDPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Download         Length: 267 bp

>T52360 NZ_CP010402:c2512166-2511900 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATCCTTATTTAAAGAAGAC
ATTTATAGAAATTGTTGAGACTTTAAAAAATGATCCTTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCTTCAGCACAGGGTCGTCTATACCATAGATGATCGAAATAAAGTAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9735.76 Da        Isoelectric Point: 4.1958

>AT52360 WP_000587619.1 NZ_CP010402:c2512423-2512166 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT52360 NZ_CP010402:c2512423-2512166 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGTAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATGT
ATCTTGTATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAGTAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1VXK4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1VMY7

References