Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2480399..2480583 Replicon chromosome
Accession NZ_CP010402
Organism Staphylococcus aureus strain GR2

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag RT44_RS12635 Protein ID WP_000482652.1
Coordinates 2480476..2480583 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2480399..2480459 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RT44_RS12610 2475854..2476021 - 168 WP_001790576.1 hypothetical protein -
RT44_RS12620 2476252..2477985 - 1734 WP_000486495.1 ABC transporter ATP-binding protein/permease -
RT44_RS12625 2478010..2479773 - 1764 WP_001064837.1 ABC transporter ATP-binding protein/permease -
- 2480399..2480459 + 61 - - Antitoxin
RT44_RS12635 2480476..2480583 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
RT44_RS12640 2480717..2481103 - 387 WP_000779357.1 flippase GtxA -
RT44_RS12645 2481371..2482513 + 1143 WP_054170588.1 glycerate kinase -
RT44_RS12650 2482573..2483232 + 660 WP_000831298.1 membrane protein -
RT44_RS12655 2483414..2484625 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
RT44_RS12660 2484748..2485221 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T52358 WP_000482652.1 NZ_CP010402:c2480583-2480476 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T52358 NZ_CP010402:c2480583-2480476 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT52358 NZ_CP010402:2480399-2480459 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References