52357

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2455093..2455610 Replicon chromosome
Accession NZ_CP010402
Organism Staphylococcus aureus strain GR2

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag RT44_RS12485 Protein ID WP_000113262.1
Coordinates 2455093..2455359 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag RT44_RS12490 Protein ID WP_000584499.1
Coordinates 2455359..2455610 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RT44_RS12460 2450522..2451058 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
RT44_RS12465 2451291..2452115 - 825 WP_000572040.1 formate/nitrite transporter family protein -
RT44_RS12470 2452332..2452514 - 183 WP_000230294.1 hypothetical protein -
RT44_RS12475 2452598..2453065 - 468 WP_000153346.1 SRPBCC domain-containing protein -
RT44_RS12480 2453251..2454798 - 1548 WP_054170587.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
RT44_RS15130 2454987..2455058 - 72 Protein_2358 hypothetical protein -
RT44_RS12485 2455093..2455359 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
RT44_RS12490 2455359..2455610 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
RT44_RS12495 2455775..2455876 - 102 Protein_2361 hypothetical protein -
RT44_RS12500 2455883..2456482 - 600 WP_000162810.1 DsbA family protein -
RT44_RS12505 2456501..2456863 - 363 WP_000819843.1 DUF4467 domain-containing protein -
RT44_RS12510 2457118..2458368 + 1251 WP_001012218.1 FemA/FemB family glycyltransferase FmhA -
RT44_RS12515 2458465..2459196 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
RT44_RS12520 2459193..2459912 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T52357 WP_000113262.1 NZ_CP010402:c2455359-2455093 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T52357 NZ_CP010402:c2455359-2455093 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT52357 WP_000584499.1 NZ_CP010402:c2455610-2455359 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT52357 NZ_CP010402:c2455610-2455359 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB T1YB60

References