Detailed information of TA system TA052349

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2021805..2022104
• Replicon: chromosome
• Accession: NZ_CP010402
• Organism: Staphylococcus aureus strain GR2

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: RT44_RS14775
• Protein ID: WP_072353918.1
• Coordinates: 2021928..2022104 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2021805..2021860 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RT44_RS10105	2017363..2017542	+	180	WP_000669791.1	hypothetical protein	-
RT44_RS10115	2017853..2018113	+	261	WP_001791826.1	hypothetical protein	-
RT44_RS10120	2018166..2018516	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
RT44_RS10125	2019027..2019362	-	336	Protein_1910	SH3 domain-containing protein	-
RT44_RS10130	2020013..2020504	-	492	WP_000920038.1	staphylokinase	-
RT44_RS10135	2020695..2021450	-	756	WP_000861038.1	CHAP domain-containing protein	-
RT44_RS10140	2021462..2021716	-	255	WP_000611512.1	phage holin	-
RT44_RS10145	2021768..2021875	+	108	WP_001791821.1	hypothetical protein	-
-	2021797..2021936	+	140	NuclAT_0	-	-
-	2021797..2021936	+	140	NuclAT_0	-	-
-	2021797..2021936	+	140	NuclAT_0	-	-
-	2021797..2021936	+	140	NuclAT_0	-	-
-	2021805..2021860	+	56	-	-	Antitoxin
RT44_RS14775	2021928..2022104	-	177	WP_072353918.1	putative holin-like toxin	Toxin
RT44_RS10150	2022247..2022621	-	375	WP_000340977.1	hypothetical protein	-
RT44_RS10155	2022677..2022964	-	288	WP_001262620.1	hypothetical protein	-
RT44_RS10160	2023010..2023162	-	153	WP_001000058.1	hypothetical protein	-
RT44_RS15115	2023155..2026937	-	3783	Protein_1919	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / hlb / groEL	2018166..2069859	51693

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6810.43 Da
• Isoelectric Point: 9.9479

>T52349 WP_072353918.1 NZ_CP010402:c2022104-2021928 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRCLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T52349 NZ_CP010402:c2022104-2021928 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGTTGGCATTACTGAAATCTTTAGAAAGGAGATGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT52349 NZ_CP010402:2021805-2021860 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Antitoxin