Detailed information of TA system TA052344

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1545290..1545869
• Replicon: chromosome
• Accession: NZ_CP010402
• Organism: Staphylococcus aureus strain GR2

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: RT44_RS07530
• Protein ID: WP_001025401.1
• Coordinates: 1545624..1545869 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1545290..1545655 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RT44_RS07490	1542032..1542589	-	558	WP_000645042.1	DUF2815 family protein	-
RT44_RS07495	1542615..1543781	-	1167	WP_000762551.1	DUF2800 domain-containing protein	-
RT44_RS07500	1543778..1544140	-	363	WP_000279446.1	hypothetical protein	-
RT44_RS07505	1544155..1544478	-	324	WP_000175000.1	hypothetical protein	-
RT44_RS07510	1544558..1544719	-	162	WP_001285955.1	DUF1270 family protein	-
RT44_RS07515	1544732..1544995	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
RT44_RS07520	1545020..1545235	-	216	WP_001036301.1	hypothetical protein	-
RT44_RS07525	1545290..1545655	+	366	WP_001128433.1	hypothetical protein	Antitoxin
RT44_RS07530	1545624..1545869	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
RT44_RS07535	1545885..1546133	-	249	WP_000272861.1	helix-turn-helix domain-containing protein	-
RT44_RS07540	1546297..1546620	+	324	WP_001260486.1	helix-turn-helix domain-containing protein	-
RT44_RS07545	1546633..1547094	+	462	WP_000525006.1	hypothetical protein	-
RT44_RS07550	1547111..1547545	+	435	WP_001226136.1	hypothetical protein	-
RT44_RS07555	1547574..1547969	+	396	WP_000449655.1	hypothetical protein	-
RT44_RS07560	1548059..1548205	+	147	WP_001013104.1	hypothetical protein	-
RT44_RS07565	1548202..1548816	-	615	WP_000191459.1	hypothetical protein	-
RT44_RS14660	1548942..1550148	+	1207	Protein_1452	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukF-PV / lukS-PV	1504696..1569522	64826

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T52344 WP_001025401.1 NZ_CP010402:c1545869-1545624 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T52344 NZ_CP010402:c1545869-1545624 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT52344 NZ_CP010402:1545290-1545655 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin