Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 70778..71369 | Replicon | chromosome |
| Accession | NZ_CP010401 | ||
| Organism | Bartonella ancashensis strain 20.00 | ||
Toxin (Protein)
| Gene name | graT | Uniprot ID | - |
| Locus tag | PU02_RS00375 | Protein ID | WP_200903957.1 |
| Coordinates | 71091..71369 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | graA | Uniprot ID | - |
| Locus tag | PU02_RS00370 | Protein ID | WP_053943597.1 |
| Coordinates | 70778..71074 (-) | Length | 99 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PU02_RS00325 | 65814..66074 | + | 261 | WP_053943592.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| PU02_RS00330 | 66145..66417 | - | 273 | WP_053943567.1 | hypothetical protein | - |
| PU02_RS00335 | 66414..67154 | - | 741 | WP_053943568.1 | antA/AntB antirepressor family protein | - |
| PU02_RS00340 | 67691..67963 | - | 273 | WP_053943569.1 | hypothetical protein | - |
| PU02_RS00345 | 68419..68694 | + | 276 | WP_053944588.1 | type II toxin-antitoxin system HigB family toxin | - |
| PU02_RS00350 | 68691..69047 | + | 357 | WP_053943593.1 | transcriptional regulator | - |
| PU02_RS00355 | 69136..69717 | - | 582 | WP_053943594.1 | phage tail protein | - |
| PU02_RS00360 | 69721..69990 | - | 270 | WP_053943595.1 | hypothetical protein | - |
| PU02_RS00365 | 70281..70676 | - | 396 | WP_053943596.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| PU02_RS00370 | 70778..71074 | - | 297 | WP_053943597.1 | HigA family addiction module antidote protein | Antitoxin |
| PU02_RS00375 | 71091..71369 | - | 279 | WP_200903957.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| PU02_RS00380 | 71543..71815 | - | 273 | WP_053943567.1 | hypothetical protein | - |
| PU02_RS00385 | 71812..72552 | - | 741 | WP_053943599.1 | antA/AntB antirepressor family protein | - |
| PU02_RS06630 | 72806..73297 | - | 492 | WP_053943600.1 | Rha family transcriptional regulator | - |
| PU02_RS06780 | 73636..73773 | - | 138 | WP_158404006.1 | hypothetical protein | - |
| PU02_RS00395 | 73824..74156 | - | 333 | WP_053943601.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
| PU02_RS00400 | 74153..74389 | - | 237 | WP_053943602.1 | antitoxin MazE family protein | - |
| PU02_RS00405 | 74902..75324 | - | 423 | WP_053943603.1 | type II toxin-antitoxin system VapC family toxin | - |
| PU02_RS06785 | 75426..75587 | - | 162 | WP_158404007.1 | hypothetical protein | - |
| PU02_RS00410 | 75666..75872 | - | 207 | WP_144417854.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 36419..85973 | 49554 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10714.29 Da Isoelectric Point: 9.5804
>T52339 WP_200903957.1 NZ_CP010401:c71369-71091 [Bartonella ancashensis]
IESFADKRCKDLLEGNPPKSFPVSLVRTAQRKLFMLDKAVELKDLRSPPGNRLEALKGDRQGQYSIRINDQFRICFEWRS
NGAYKVEIVDYH
IESFADKRCKDLLEGNPPKSFPVSLVRTAQRKLFMLDKAVELKDLRSPPGNRLEALKGDRQGQYSIRINDQFRICFEWRS
NGAYKVEIVDYH
Download Length: 279 bp
>T52339 NZ_CP010401:c71369-71091 [Bartonella ancashensis]
ATCGAATCCTTTGCTGATAAGCGATGTAAGGATCTTTTAGAAGGAAATCCGCCCAAAAGTTTTCCTGTGTCTTTAGTGCG
TACAGCTCAAAGAAAATTGTTCATGCTGGATAAAGCTGTTGAACTTAAGGATCTGCGTAGTCCTCCAGGCAATCGTTTAG
AAGCATTGAAAGGTGACCGCCAAGGCCAATATTCCATCCGTATTAATGACCAATTTCGTATTTGTTTTGAGTGGCGTTCT
AATGGCGCTTATAAAGTTGAAATTGTAGATTATCATTAA
ATCGAATCCTTTGCTGATAAGCGATGTAAGGATCTTTTAGAAGGAAATCCGCCCAAAAGTTTTCCTGTGTCTTTAGTGCG
TACAGCTCAAAGAAAATTGTTCATGCTGGATAAAGCTGTTGAACTTAAGGATCTGCGTAGTCCTCCAGGCAATCGTTTAG
AAGCATTGAAAGGTGACCGCCAAGGCCAATATTCCATCCGTATTAATGACCAATTTCGTATTTGTTTTGAGTGGCGTTCT
AATGGCGCTTATAAAGTTGAAATTGTAGATTATCATTAA
Antitoxin
Download Length: 99 a.a. Molecular weight: 11279.01 Da Isoelectric Point: 5.1546
>AT52339 WP_053943597.1 NZ_CP010401:c71074-70778 [Bartonella ancashensis]
MKNYIAIHPGEILREEYLKEYALSAYALAKALNVPRTRIERIVAENSPITPDTAVRLAYFFDTTAEFWLNMQAAYDVNIL
QAEKAEEFAKIDKFKCMA
MKNYIAIHPGEILREEYLKEYALSAYALAKALNVPRTRIERIVAENSPITPDTAVRLAYFFDTTAEFWLNMQAAYDVNIL
QAEKAEEFAKIDKFKCMA
Download Length: 297 bp
>AT52339 NZ_CP010401:c71074-70778 [Bartonella ancashensis]
ATGAAAAATTATATAGCCATTCACCCAGGAGAAATTTTGCGCGAAGAATATTTAAAAGAATATGCTCTTTCTGCTTATGC
GCTTGCAAAAGCATTAAATGTTCCACGCACGCGCATAGAGCGTATTGTCGCTGAAAATAGTCCTATAACCCCTGATACAG
CAGTAAGGTTAGCTTATTTTTTTGATACCACAGCTGAATTTTGGCTAAACATGCAAGCTGCTTATGATGTTAATATATTG
CAAGCGGAAAAAGCAGAAGAATTTGCTAAAATAGACAAATTTAAATGTATGGCTTAA
ATGAAAAATTATATAGCCATTCACCCAGGAGAAATTTTGCGCGAAGAATATTTAAAAGAATATGCTCTTTCTGCTTATGC
GCTTGCAAAAGCATTAAATGTTCCACGCACGCGCATAGAGCGTATTGTCGCTGAAAATAGTCCTATAACCCCTGATACAG
CAGTAAGGTTAGCTTATTTTTTTGATACCACAGCTGAATTTTGGCTAAACATGCAAGCTGCTTATGATGTTAATATATTG
CAAGCGGAAAAAGCAGAAGAATTTGCTAAAATAGACAAATTTAAATGTATGGCTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|