Detailed information of TA system TA052338

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 4064..4715
• Replicon: plasmid p6200-9.327kb
• Accession: NZ_CP010400
• Organism: Acinetobacter baumannii strain 6200

Toxin (Protein)

• Gene name: higB
• Uniprot ID: V2UF49
• Locus tag: RU84_RS19345
• Protein ID: WP_000269909.1
• Coordinates: 4064..4420 (+)
• Length: 119 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: RU84_RS19350
• Protein ID: WP_001140621.1
• Coordinates: 4413..4715 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RU84_RS19330	627..818	+	192	WP_000102616.1	hypothetical protein	-
RU84_RS19335	905..1756	-	852	WP_002115246.1	universal stress protein	-
RU84_RS19340	1769..3256	-	1488	WP_005108963.1	SulP family inorganic anion transporter	-
RU84_RS19345	4064..4420	+	357	WP_000269909.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
RU84_RS19350	4413..4715	+	303	WP_001140621.1	XRE family transcriptional regulator	Antitoxin
RU84_RS19355	4708..4917	+	210	WP_000069475.1	hypothetical protein	-
RU84_RS19360	5092..5610	+	519	WP_000447196.1	sel1 repeat family protein	-
RU84_RS19365	5649..6161	+	513	WP_001089572.1	SMI1/KNR4 family protein	-
RU84_RS19370	6268..6585	-	318	WP_000900860.1	hypothetical protein	-
RU84_RS19375	7014..7538	-	525	WP_005127114.1	plasmid replication DNA-binding protein	-
RU84_RS19380	7617..8546	-	930	WP_038350249.1	replication initiation protein RepM	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..9327	9327

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-106)

Antitoxin

• HigA2-like, helix-turn-helix domain (14-89)

Sequences

Toxin

Protein

• Length: 119 a.a.
• Molecular weight: 13515.49 Da
• Isoelectric Point: 6.4631

>T52338 WP_000269909.1 NZ_CP010400:4064-4420 [Acinetobacter baumannii]
MWTVITTDLFNEWLVQQDESTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKGGKKRFYKEMLDIADQQYELHLSTLGDQSNG

Nucleotide

• Length: 357 bp

>T52338 NZ_CP010400:4064-4420 [Acinetobacter baumannii]
ATGTGGACAGTCATTACAACGGATCTGTTTAACGAATGGCTTGTACAGCAAGATGAATCTACACAAGAGAAAGTACTCGC
AGCGTTGGTCGTTCTACAGCAACAGGGACCAAGTTTAGGTCGTCCTTTAGTAGATACCGTCTATGACTCCAAATTTACCA
ACATGAAAGAGCTACGTGTTCAGCATCGAGGTAAACCACTGAGAGCCTTTTTCGCATTTGATCCTTTACGACAAGCTATT
GTGCTGTGTATCGGTGATAAAGGCGGTAAAAAGCGTTTTTATAAAGAGATGTTAGATATTGCCGATCAGCAATACGAACT
TCATCTTTCAACTTTAGGAGATCAATCTAATGGCTAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11179.02 Da
• Isoelectric Point: 7.3198

>AT52338 WP_001140621.1 NZ_CP010400:4413-4715 [Acinetobacter baumannii]
MAKTLQELLASRSPESQARIQKMADELLLETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Nucleotide

• Length: 303 bp

>AT52338 NZ_CP010400:4413-4715 [Acinetobacter baumannii]
ATGGCTAAGACCCTACAAGAATTATTGGCTAGTCGCTCTCCAGAGAGTCAAGCTCGTATTCAAAAAATGGCTGATGAATT
ACTGTTGGAAACTCAGCTTCACCTTATTCGTGAAGAGTTGGAGATTTCTCAAAAAGAACTGGCTGCAACCCTTGGAATCA
AACAGCCGTCATTGTCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACGATGAAAAAGTATGTTGAAGCAATG
GGCGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACACATAGGATTTAATGTCTAA

Structures

Toxin

• AlphaFold DB: V2UF49