Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 136814..137471 | Replicon | plasmid p6409-202.186kb |
| Accession | NZ_CP010373 | ||
| Organism | Escherichia coli strain 6409 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | U3PDC3 |
| Locus tag | RR31_RS25275 | Protein ID | WP_000270043.1 |
| Coordinates | 136814..137164 (+) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | RR31_RS25280 | Protein ID | WP_000124640.1 |
| Coordinates | 137169..137471 (+) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| RR31_RS25235 | 132480..132857 | + | 378 | WP_000656305.1 | GNAT family N-acetyltransferase | - |
| RR31_RS25240 | 133058..133717 | - | 660 | WP_000412211.1 | type A-1 chloramphenicol O-acetyltransferase | - |
| RR31_RS25245 | 133996..134693 | + | 698 | Protein_148 | IS1 family transposase | - |
| RR31_RS25250 | 134723..135193 | - | 471 | WP_001281821.1 | hypothetical protein | - |
| RR31_RS28535 | 135186..135557 | - | 372 | WP_000516916.1 | hypothetical protein | - |
| RR31_RS28540 | 135568..135762 | - | 195 | WP_000343597.1 | hypothetical protein | - |
| RR31_RS25270 | 136103..136651 | - | 549 | WP_001061574.1 | transcriptional regulator | - |
| RR31_RS25275 | 136814..137164 | + | 351 | WP_000270043.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| RR31_RS25280 | 137169..137471 | + | 303 | WP_000124640.1 | XRE family transcriptional regulator | Antitoxin |
| RR31_RS25285 | 137498..137791 | - | 294 | WP_001239997.1 | chromosome segregation protein ParM | - |
| RR31_RS25290 | 137879..138151 | - | 273 | WP_001043047.1 | HU family DNA-binding protein | - |
| RR31_RS25295 | 138209..138736 | - | 528 | WP_040110415.1 | thermonuclease family protein | - |
| RR31_RS25300 | 138753..138941 | - | 189 | WP_001270411.1 | hypothetical protein | - |
| RR31_RS25305 | 138967..139824 | - | 858 | WP_001167032.1 | hypothetical protein | - |
| RR31_RS25310 | 139811..140041 | - | 231 | WP_000972663.1 | hypothetical protein | - |
| RR31_RS25315 | 140041..140559 | - | 519 | WP_000210756.1 | nitrite reductase | - |
| RR31_RS25320 | 140556..141002 | - | 447 | WP_000919345.1 | Fe3+-siderophore ABC transporter permease | - |
| RR31_RS25325 | 141002..141361 | - | 360 | WP_000422768.1 | hypothetical protein | - |
| RR31_RS25330 | 141418..141846 | - | 429 | WP_000591074.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | blaNDM-1 / aph(3'')-Ib / aph(6)-Id / aac(6')-Ian / tet(B) / sul1 / qacE / aadA10 / dfrA1 / catA1 | htpB / htpB / htpB | 1..193908 | 193908 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 13328.21 Da Isoelectric Point: 5.2421
>T52265 WP_000270043.1 NZ_CP010373:136814-137164 [Escherichia coli]
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
Download Length: 351 bp
>T52265 NZ_CP010373:136814-137164 [Escherichia coli]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11006.73 Da Isoelectric Point: 7.2036
>AT52265 WP_000124640.1 NZ_CP010373:137169-137471 [Escherichia coli]
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
Download Length: 303 bp
>AT52265 NZ_CP010373:137169-137471 [Escherichia coli]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|