52246

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2168579..2169081 Replicon chromosome
Accession NZ_CP010371
Organism Escherichia coli strain 6409

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag RR31_RS10885 Protein ID WP_000767829.1
Coordinates 2168579..2168833 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag RR31_RS10890 Protein ID WP_001259255.1
Coordinates 2168830..2169081 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RR31_RS10860 2163594..2163821 - 228 WP_000985273.1 sulfurtransferase TusA family protein -
RR31_RS10865 2163835..2164893 - 1059 WP_000492321.1 transport protein YeeE -
RR31_RS10870 2165072..2166430 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
RR31_RS28805 2166420..2166482 - 63 WP_010723108.1 membrane protein YoeI -
RR31_RS10875 2166697..2167626 - 930 WP_000803351.1 LysR family transcriptional regulator -
RR31_RS10880 2167672..2168496 - 825 WP_000754749.1 SDR family oxidoreductase -
RR31_RS10885 2168579..2168833 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
RR31_RS10890 2168830..2169081 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
RR31_RS26580 2169364..2169414 + 51 WP_001364200.1 his operon leader peptide -
RR31_RS10895 2169560..2170459 + 900 WP_000131777.1 ATP phosphoribosyltransferase -
RR31_RS10900 2170465..2171769 + 1305 WP_001614652.1 histidinol dehydrogenase -
RR31_RS10905 2171766..2172836 + 1071 WP_000108939.1 histidinol-phosphate transaminase -
RR31_RS10910 2172836..2173903 + 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T52246 WP_000767829.1 NZ_CP010371:c2168833-2168579 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T52246 NZ_CP010371:c2168833-2168579 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT52246 WP_001259255.1 NZ_CP010371:c2169081-2168830 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT52246 NZ_CP010371:c2169081-2168830 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References