Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 10303..10912 Replicon plasmid p6411-89.111kb
Accession NZ_CP010369
Organism Acinetobacter nosocomialis strain 6411

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag RR32_RS18205 Protein ID WP_000269908.1
Coordinates 10303..10659 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag RR32_RS18210 Protein ID WP_002120200.1
Coordinates 10652..10912 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RR32_RS19750 6280..7412 + 1133 Protein_3 IS3 family transposase -
RR32_RS18190 7768..8088 - 321 WP_001081101.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
RR32_RS18195 8331..8859 - 529 Protein_5 IS3 family transposase -
RR32_RS18200 9064..9745 - 682 Protein_6 hypothetical protein -
RR32_RS18205 10303..10659 + 357 WP_000269908.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
RR32_RS18210 10652..10912 + 261 WP_002120200.1 helix-turn-helix transcriptional regulator Antitoxin
RR32_RS18225 12058..12267 - 210 WP_000069470.1 hypothetical protein -
RR32_RS18230 12260..12562 - 303 WP_001140619.1 XRE family transcriptional regulator -
RR32_RS18235 12603..12911 - 309 WP_000269910.1 type II toxin-antitoxin system RelE/ParE family toxin -
RR32_RS19760 13926..14042 - 117 Protein_12 transposase -
RR32_RS18240 14229..14522 - 294 WP_000221360.1 type II toxin-antitoxin system RelE/ParE family toxin -
RR32_RS18245 14512..14757 - 246 WP_000246757.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..89111 89111


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(14-83)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13622.56 Da        Isoelectric Point: 6.4651

>T52227 WP_000269908.1 NZ_CP010369:10303-10659 [Acinetobacter nosocomialis]
MWTVITTDLFNEWLEQQDESTQEKVLTALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPFRQAI
VLCIGDKGGKKRFYKEMLNIAEQQYELHLSTLGDQSNG

Download         Length: 357 bp

>T52227 NZ_CP010369:10303-10659 [Acinetobacter nosocomialis]
ATGTGGACAGTCATCACGACAGATCTGTTTAATGAATGGCTTGAACAGCAAGACGAATCAACACAAGAGAAAGTCTTAAC
CGCTTTAGTTGTTTTACAGCAGCAGGGACCAAGTTTAGGTCGCCCTTTAGTTGATACCGTATATGACTCTAAATTTACCA
ATATGAAAGAGCTACGCGTTCAGCATCGAGGAAAACCCCTGAGAGCCTTTTTCGCATTTGATCCATTTCGACAGGCAATT
GTGCTGTGCATCGGTGATAAAGGCGGTAAAAAGCGTTTCTATAAAGAGATGCTGAACATTGCAGAGCAGCAATACGAACT
TCATCTCTCAACCCTTGGAGATCAATCTAATGGCTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9692.11 Da        Isoelectric Point: 4.8223

>AT52227 WP_002120200.1 NZ_CP010369:10652-10912 [Acinetobacter nosocomialis]
MAKTLQELLASRSPESQTRIQQMADELLLETQLHFIREELEISQKELAATLGIKQPSLSAIENRGNDLKISTMKKYVEAM
GGETPY

Download         Length: 261 bp

>AT52227 NZ_CP010369:10652-10912 [Acinetobacter nosocomialis]
ATGGCTAAAACCTTACAGGAATTATTGGCTAGTCGCTCTCCAGAGAGCCAAACTCGTATTCAACAAATGGCTGACGAGCT
ACTTTTAGAAACTCAGCTTCACTTTATTCGAGAAGAATTAGAGATTTCCCAAAAGGAACTGGCTGCAACTCTTGGAATCA
AACAACCTTCATTGTCAGCAATCGAAAACCGTGGCAATGATCTTAAGATTTCAACCATGAAAAAGTATGTTGAAGCTATG
GGGGGGGAAACTCCGTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References