Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | unclassified/- |
Location | 2974761..2975409 | Replicon | chromosome |
Accession | NZ_CP010339 | ||
Organism | Mycobacterium tuberculosis strain 22103 |
Toxin (Protein)
Gene name | novel[antitoxin] | Uniprot ID | P9WJ12 |
Locus tag | RN14_RS13940 | Protein ID | WP_003899414.1 |
Coordinates | 2974761..2975084 (-) | Length | 108 a.a. |
Antitoxin (Protein)
Gene name | novel[toxin] | Uniprot ID | P9WJ10 |
Locus tag | RN14_RS13945 | Protein ID | WP_003899415.1 |
Coordinates | 2975164..2975409 (-) | Length | 82 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
RN14_RS13910 (RN14_2813) | 2970084..2971082 | + | 999 | WP_034163937.1 | tyrosine-type recombinase/integrase | - |
RN14_RS13915 (RN14_2814) | 2971096..2971560 | + | 465 | WP_003900539.1 | ParB N-terminal domain-containing protein | - |
RN14_RS13920 | 2971548..2971799 | + | 252 | WP_003908028.1 | hypothetical protein | - |
RN14_RS13925 (RN14_2816) | 2971970..2973409 | - | 1440 | WP_003899411.1 | phage major capsid protein | - |
RN14_RS13930 (RN14_2817) | 2973417..2973950 | - | 534 | WP_003899412.1 | HK97 family phage prohead protease | - |
RN14_RS21420 (RN14_2818) | 2974103..2974594 | - | 492 | WP_003900541.1 | phage terminase small subunit P27 family | - |
RN14_RS13940 (RN14_2819) | 2974761..2975084 | - | 324 | WP_003899414.1 | type II toxin-antitoxin system toxin | Toxin |
RN14_RS13945 (RN14_2820) | 2975164..2975409 | - | 246 | WP_003899415.1 | type II toxin-antitoxin system antitoxin | Antitoxin |
RN14_RS13950 (RN14_2821) | 2975406..2976833 | - | 1428 | WP_003899416.1 | DUF3631 domain-containing protein | - |
RN14_RS13955 (RN14_2822) | 2976835..2977227 | - | 393 | WP_003899417.1 | DUF2742 domain-containing protein | - |
RN14_RS13960 (RN14_2823) | 2977224..2977484 | - | 261 | WP_003899418.1 | helix-turn-helix domain-containing protein | - |
RN14_RS13965 (RN14_2824) | 2977501..2977863 | - | 363 | WP_003900543.1 | hypothetical protein | - |
RN14_RS13970 (RN14_2825) | 2977866..2978993 | - | 1128 | WP_003899420.1 | site-specific integrase | - |
RN14_RS13975 | 2979138..2979365 | - | 228 | WP_003899421.1 | hypothetical protein | - |
RN14_RS21425 | 2979362..2979751 | - | 390 | WP_003899422.1 | hypothetical protein | - |
RN14_RS13980 (RN14_2827) | 2979657..2979929 | + | 273 | WP_003900544.1 | hypothetical protein | - |
RN14_RS13985 (RN14_2828) | 2980028..2980261 | + | 234 | WP_003413717.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Prophage | - | - | 2970084..2978993 | 8909 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 108 a.a. Molecular weight: 12359.82 Da Isoelectric Point: 8.6717
>T52160 WP_003899414.1 NZ_CP010339:c2975084-2974761 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ
Download Length: 324 bp
>T52160 NZ_CP010339:c2975084-2974761 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA
Antitoxin
Download Length: 82 a.a. Molecular weight: 7697.71 Da Isoelectric Point: 4.8565
>AT52160 WP_003899415.1 NZ_CP010339:c2975409-2975164 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P
Download Length: 246 bp
>AT52160 NZ_CP010339:c2975409-2975164 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTCTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTCTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A045IHC4 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A806JR81 |