Detailed information of TA system TA052049

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1440315..1440970
• Replicon: chromosome
• Accession: NZ_CP010323
• Organism: Bordetella pertussis 137

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: Q425_RS06980
• Protein ID: WP_047122780.1
• Coordinates: 1440315..1440566 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q7VY40
• Locus tag: Q425_RS06985
• Protein ID: WP_003809516.1
• Coordinates: 1440569..1440970 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Q425_RS06955	1435476..1436606	-	1131	WP_010930401.1	helix-turn-helix transcriptional regulator	-
Q425_RS06960	1436841..1437422	+	582	WP_019247931.1	molybdenum cofactor biosysynthesis protein	-
Q425_RS06965	1437559..1438623	+	1065	WP_003809510.1	fructose-bisphosphate aldolase class II	-
Q425_RS06970	1438708..1439154	-	447	WP_003819827.1	GFA family protein	-
Q425_RS06975	1439379..1440260	+	882	WP_003809513.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
Q425_RS06980	1440315..1440566	+	252	WP_047122780.1	type II toxin-antitoxin system MqsR family toxin	Toxin
Q425_RS06985	1440569..1440970	+	402	WP_003809516.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
Q425_RS19950	1440990..1441226	+	237	WP_010930404.1	membrane protein	-
Q425_RS06990	1441234..1441713	+	480	WP_010930405.1	disulfide bond formation protein B	-
Q425_RS06995	1441863..1442378	+	516	WP_019247930.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
Q425_RS07000	1442381..1443571	+	1191	WP_010930406.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
Q425_RS07005	1443591..1444628	+	1038	WP_023853543.1	threonylcarbamoyl-AMP synthase	-
Q425_RS07010	1444765..1445787	+	1023	WP_003809532.1	amino acid ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (10-82)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 8952.52 Da
• Isoelectric Point: 9.7242

>T52049 WP_047122780.1 NZ_CP010323:1440315-1440566 [Bordetella pertussis 137]
IGGAATKKPGQKRRAGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPIVSF
KEL

Nucleotide

• Length: 252 bp

>T52049 NZ_CP010323:1440315-1440566 [Bordetella pertussis 137]
ATTGGAGGCGCGGCGACAAAAAAGCCGGGACAAAAGCGTCGCGCCGGGGCGGCGGCGCTGGGGCTGGATTTCAGCGCCAT
GGTCGAAATCGTGCTTGCATTGACACCGCGGGATTTCCACAAAAGCATGACTACCCATGCCGACCATCGCATTTGGCAGG
ACGTCTATTGCCCGGTGACAGCGATGGGCGCCGTCTACCTGAAGCTGACGGTCCTCGACGGCGTGCCGATCGTGTCGTTC
AAGGAGTTGTGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14528.70 Da
• Isoelectric Point: 8.5005

>AT52049 WP_003809516.1 NZ_CP010323:1440569-1440970 [Bordetella pertussis 137]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Nucleotide

• Length: 402 bp

>AT52049 NZ_CP010323:1440569-1440970 [Bordetella pertussis 137]
ATGAAGTGTCCCGTATGCGGAGCGGCCGCGCTGGCGCGTGATACTCGCGATGTGCCCTATAGCTACAAGGGCGAGACCAT
CACGATTGCGGCGGTGACGGGCGACTGGTGTCCGGCATGCGGCGAGAACGTGCTCGATGGCGCTGAATCGGCGCGGGTGA
GCGAGGCCATGCTGGCTTTCAACCGCCTGGTCAACGCCCGCCGCGTCGACCCCGGGTTCATCGTGCGGGTGCGCAGGAAG
CTGGGGCTGGACCAGCGCGAAGCCGCGGCGCTGTTCGGCGGCGGCACCAATGCGTTCTCGCGTTACGAGAACGGCAAGAC
GCGCCCGCCGCTGGCGCTGGTGAAGCTGCTCAGGCTGCTGGATCGCCATCCGGAGCTGCTGGAGGAAGTCCGTGCGGATT
GA

Structures

Antitoxin

• AlphaFold DB: A0A0H3LKS6