Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3468186..3468879 Replicon chromosome
Accession NZ_CP010315
Organism Escherichia coli strain 789

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag AC789_RS17095 Protein ID WP_000415584.1
Coordinates 3468583..3468879 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag AC789_RS17090 Protein ID WP_000650107.1
Coordinates 3468186..3468581 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AC789_RS17080 3464050..3466308 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
AC789_RS17085 3466446..3468053 - 1608 WP_001324265.1 ABC transporter substrate-binding protein -
AC789_RS17090 3468186..3468581 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
AC789_RS17095 3468583..3468879 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
AC789_RS17100 3469084..3469566 - 483 WP_000183494.1 transcriptional regulator -
AC789_RS17105 3469619..3470011 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
AC789_RS17110 3470163..3470822 + 660 WP_001221491.1 two-component system response regulator QseB -
AC789_RS17115 3470819..3472168 + 1350 WP_000673406.1 two-component system sensor histidine kinase QseC -
AC789_RS17120 3472278..3472859 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
AC789_RS17125 3472890..3473204 + 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T52034 WP_000415584.1 NZ_CP010315:c3468879-3468583 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T52034 NZ_CP010315:c3468879-3468583 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT52034 WP_000650107.1 NZ_CP010315:c3468581-3468186 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT52034 NZ_CP010315:c3468581-3468186 [Escherichia coli]
ATGAAATGTCCGGTTTGCCATCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References