Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
Location | 2352578..2353080 | Replicon | chromosome |
Accession | NZ_CP010315 | ||
Organism | Escherichia coli strain 789 |
Toxin (Protein)
Gene name | yoeB | Uniprot ID | D3GZ85 |
Locus tag | AC789_RS11715 | Protein ID | WP_000767820.1 |
Coordinates | 2352578..2352832 (-) | Length | 85 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | S1Q063 |
Locus tag | AC789_RS11720 | Protein ID | WP_001259255.1 |
Coordinates | 2352829..2353080 (-) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
AC789_RS11690 | 2347593..2347820 | - | 228 | WP_000985273.1 | sulfurtransferase TusA family protein | - |
AC789_RS11695 | 2347834..2348892 | - | 1059 | WP_000492324.1 | transport protein YeeE | - |
AC789_RS11700 | 2349071..2350429 | - | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
AC789_RS29450 | 2350419..2350481 | - | 63 | WP_010723108.1 | membrane protein YoeI | - |
AC789_RS11705 | 2350696..2351625 | - | 930 | WP_000803351.1 | LysR family transcriptional regulator | - |
AC789_RS11710 | 2351671..2352495 | - | 825 | WP_000754756.1 | SDR family oxidoreductase | - |
AC789_RS11715 | 2352578..2352832 | - | 255 | WP_000767820.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
AC789_RS11720 | 2352829..2353080 | - | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
AC789_RS27335 | 2353364..2353414 | + | 51 | WP_001364200.1 | his operon leader peptide | - |
AC789_RS11725 | 2353560..2354459 | + | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
AC789_RS11730 | 2354465..2355769 | + | 1305 | WP_039025710.1 | histidinol dehydrogenase | - |
AC789_RS11735 | 2355766..2356836 | + | 1071 | WP_000108952.1 | histidinol-phosphate transaminase | - |
AC789_RS11740 | 2356836..2357903 | + | 1068 | WP_000080077.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10182.64 Da Isoelectric Point: 8.0353
>T52029 WP_000767820.1 NZ_CP010315:c2352832-2352578 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKIIELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKIIELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T52029 NZ_CP010315:c2352832-2352578 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAGTCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CATTGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAGCATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
GTGAAACTAATCTGGTCTGAGGAGTCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CATTGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAGCATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT52029 WP_001259255.1 NZ_CP010315:c2353080-2352829 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT52029 NZ_CP010315:c2353080-2352829 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGCCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA
ATGCGTACAATTAGCTACAGCGAAGCGCGCCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | D3GZ85 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9LNR0 |