Detailed information of TA system TA051982

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 1794730..1795232
• Replicon: chromosome
• Accession: NZ_CP010311
• Organism: Geoalkalibacter subterraneus strain Red1

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A0A0B5FGV5
• Locus tag: GSUB_RS08290
• Protein ID: WP_040200207.1
• Coordinates: 1794730..1794993 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A0B5FPI6
• Locus tag: GSUB_RS08295
• Protein ID: WP_040200208.1
• Coordinates: 1794990..1795232 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GSUB_RS08255	1789819..1791498	+	1680	WP_158414063.1	fibronectin-binding domain-containing protein	-
GSUB_RS08260	1791729..1792508	+	780	WP_040200199.1	type I methionyl aminopeptidase	-
GSUB_RS08265	1792558..1792917	+	360	WP_040200200.1	DUF1622 domain-containing protein	-
GSUB_RS08270	1792938..1793258	+	321	WP_040200201.1	quaternary ammonium compound efflux SMR transporter SugE	-
GSUB_RS08275	1793281..1793985	+	705	WP_040200203.1	MgtC/SapB family protein	-
GSUB_RS08280	1794012..1794410	+	399	WP_040200204.1	hypothetical protein	-
GSUB_RS08285	1794437..1794688	+	252	WP_144401991.1	hypothetical protein	-
GSUB_RS08290	1794730..1794993	-	264	WP_040200207.1	Txe/YoeB family addiction module toxin	Toxin
GSUB_RS08295	1794990..1795232	-	243	WP_040200208.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GSUB_RS08300	1795298..1795696	-	399	WP_040200209.1	peptide-methionine (R)-S-oxide reductase MsrB	-
GSUB_RS08305	1796029..1796388	+	360	WP_040200213.1	hypothetical protein	-
GSUB_RS08310	1796425..1796724	-	300	WP_052464767.1	DUF2959 family protein	-
GSUB_RS08315	1796878..1798185	+	1308	WP_040200215.1	hypothetical protein	-
GSUB_RS08320	1798434..1798979	-	546	WP_040200217.1	peptide-methionine (S)-S-oxide reductase MsrA	-
GSUB_RS08325	1799279..1799995	+	717	WP_040200219.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (23-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10228.00 Da
• Isoelectric Point: 10.2852

>T51982 WP_040200207.1 NZ_CP010311:c1794993-1794730 [Geoalkalibacter subterraneus]
VSWKIVYTKQAQKDAKKLSASGMKPKAWRLLEIIAENPYQTPPPYEKLVGDLAGAYSRRINIQHRLVYQVLEEIKTIKVL
RMWTHYE

Nucleotide

• Length: 264 bp

>T51982 NZ_CP010311:c1794993-1794730 [Geoalkalibacter subterraneus]
GTGAGTTGGAAGATTGTTTACACCAAGCAGGCCCAAAAGGATGCAAAAAAACTCTCCGCATCGGGCATGAAGCCAAAAGC
CTGGCGACTGCTCGAAATAATTGCGGAGAATCCATATCAGACCCCGCCACCGTATGAGAAACTTGTCGGTGACTTGGCAG
GAGCCTATTCAAGAAGGATCAACATCCAGCACCGGCTCGTCTATCAGGTCCTGGAAGAGATTAAGACGATCAAGGTGCTG
CGGATGTGGACACATTACGAATAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9111.32 Da
• Isoelectric Point: 4.4664

>AT51982 WP_040200208.1 NZ_CP010311:c1795232-1794990 [Geoalkalibacter subterraneus]
MPTITATEARKSLYRILDQVSETHEPIQITGKRGNAILISEDDWRAIQETLYLHSIPGVKDSIIEGMKTPVDECDKELDW

Nucleotide

• Length: 243 bp

>AT51982 NZ_CP010311:c1795232-1794990 [Geoalkalibacter subterraneus]
ATGCCGACAATCACTGCGACCGAAGCAAGAAAGAGCCTGTACCGCATCCTCGATCAGGTTTCAGAAACCCATGAACCGAT
ACAGATCACGGGCAAGCGTGGCAATGCTATTTTGATTTCTGAAGATGATTGGAGGGCCATCCAGGAAACACTTTATCTTC
ACTCAATTCCCGGGGTGAAAGACTCGATCATTGAAGGGATGAAAACACCCGTCGACGAGTGTGACAAGGAACTCGACTGG
TGA

Structures

Toxin

• AlphaFold DB: A0A0B5FGV5

Antitoxin

• AlphaFold DB: A0A0B5FPI6