Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-agrB/SymE(toxin)
Location 5427456..5427868 Replicon chromosome
Accession NZ_CP010304
Organism Escherichia coli O157:H7 str. SS52

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag SS52_RS27970 Protein ID WP_000132630.1
Coordinates 5427456..5427797 (-) Length 114 a.a.

Antitoxin (RNA)


Gene name agrB
Locus tag -
Coordinates 5427792..5427868 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SS52_RS33475 5423024..5423224 + 201 WP_001310455.1 hypothetical protein -
SS52_RS27950 5423467..5424879 - 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -
SS52_RS27955 5425056..5425220 + 165 WP_000394274.1 DUF1127 domain-containing protein -
SS52_RS27960 5425317..5426198 + 882 WP_001304007.1 DUF262 domain-containing protein -
SS52_RS31330 5426246..5427409 + 1164 WP_001304006.1 DUF1524 domain-containing protein -
SS52_RS27970 5427456..5427797 - 342 WP_000132630.1 endoribonuclease SymE Toxin
- 5427792..5427868 + 77 NuclAT_14 - Antitoxin
- 5427792..5427868 + 77 NuclAT_14 - Antitoxin
- 5427792..5427868 + 77 NuclAT_14 - Antitoxin
- 5427792..5427868 + 77 NuclAT_14 - Antitoxin
- 5427792..5427868 + 77 NuclAT_15 - Antitoxin
- 5427792..5427868 + 77 NuclAT_15 - Antitoxin
- 5427792..5427868 + 77 NuclAT_15 - Antitoxin
- 5427792..5427868 + 77 NuclAT_15 - Antitoxin
SS52_RS27975 5428018..5429772 - 1755 WP_000110082.1 restriction endonuclease subunit S -
SS52_RS27980 5429772..5431241 - 1470 WP_001302468.1 type I restriction-modification system subunit M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 5416949..5435669 18720


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T51971 WP_000132630.1 NZ_CP010304:c5427797-5427456 [Escherichia coli O157:H7 str. SS52]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T51971 NZ_CP010304:c5427797-5427456 [Escherichia coli O157:H7 str. SS52]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin


Download         Length: 77 bp

>AT51971 NZ_CP010304:5427792-5427868 [Escherichia coli O157:H7 str. SS52]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References