Detailed information of TA system TA051967

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-ohsC/Ldr(toxin)
• Location: 4461774..4461995
• Replicon: chromosome
• Accession: NZ_CP010304
• Organism: Escherichia coli O157:H7 str. SS52

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: SS52_RS32215
• Protein ID: WP_001295224.1
• Coordinates: 4461774..4461881 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	ohsC
Locus tag	-
Coordinates	4461930..4461995 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SS52_RS23240	4457027..4457779	-	753	Protein_4384	cellulose biosynthesis protein BcsQ	-
SS52_RS23250	4457791..4457979	-	189	WP_001063316.1	YhjR family protein	-
SS52_RS23255	4458252..4459823	+	1572	WP_001204920.1	cellulose biosynthesis protein BcsE	-
SS52_RS23260	4459820..4460011	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
SS52_RS23265	4460008..4461687	+	1680	WP_000191596.1	cellulose biosynthesis protein BcsG	-
SS52_RS32215	4461774..4461881	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	4461930..4461995	+	66	NuclAT_16	-	Antitoxin
-	4461930..4461995	+	66	NuclAT_16	-	Antitoxin
-	4461930..4461995	+	66	NuclAT_16	-	Antitoxin
-	4461930..4461995	+	66	NuclAT_16	-	Antitoxin
-	4461930..4461995	+	66	NuclAT_21	-	Antitoxin
-	4461930..4461995	+	66	NuclAT_21	-	Antitoxin
-	4461930..4461995	+	66	NuclAT_21	-	Antitoxin
-	4461930..4461995	+	66	NuclAT_21	-	Antitoxin
SS52_RS23280	4462357..4463628	+	1272	WP_001301684.1	amino acid permease	-
SS52_RS23285	4463658..4464662	-	1005	WP_000107027.1	dipeptide ABC transporter ATP-binding subunit DppF	-
SS52_RS23290	4464659..4465642	-	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
SS52_RS23295	4465653..4466555	-	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T51967 WP_001295224.1 NZ_CP010304:c4461881-4461774 [Escherichia coli O157:H7 str. SS52]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T51967 NZ_CP010304:c4461881-4461774 [Escherichia coli O157:H7 str. SS52]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 66 bp

>AT51967 NZ_CP010304:4461930-4461995 [Escherichia coli O157:H7 str. SS52]
GTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin