51944

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1396704..1397499 Replicon chromosome
Accession NZ_CP010304
Organism Escherichia coli O157:H7 str. SS52

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag SS52_RS06840 Protein ID WP_000854914.1
Coordinates 1397125..1397499 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0B0VS41
Locus tag SS52_RS06835 Protein ID WP_001280954.1
Coordinates 1396704..1397078 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SS52_RS06795 1392059..1392964 + 906 WP_000203541.1 chemotaxis protein -
SS52_RS06800 1392961..1394031 + 1071 WP_000102669.1 patatin-like phospholipase family protein -
SS52_RS06810 1394371..1395189 + 819 WP_001234682.1 DUF945 domain-containing protein -
SS52_RS06815 1395280..1395765 + 486 WP_000214398.1 antirestriction protein -
SS52_RS06820 1395781..1396257 + 477 WP_001186738.1 RadC family protein -
SS52_RS06825 1396320..1396541 + 222 WP_001220314.1 DUF987 domain-containing protein -
SS52_RS06835 1396704..1397078 + 375 WP_001280954.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
SS52_RS06840 1397125..1397499 + 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
SS52_RS06845 1397496..1397987 + 492 WP_000976853.1 hypothetical protein -
SS52_RS06850 1397999..1398196 + 198 WP_000839282.1 DUF957 domain-containing protein -
SS52_RS06855 1398281..1399123 + 843 WP_001280481.1 DUF4942 domain-containing protein -
SS52_RS06865 1399594..1400532 + 939 WP_000351284.1 glyoxylate/hydroxypyruvate reductase GhrA -
SS52_RS06870 1400587..1401324 + 738 WP_000283664.1 zinc-binding phosphatase -
SS52_RS06875 1401348..1401902 + 555 WP_001001917.1 molecular chaperone YcdY -
SS52_RS06880 1402004..1402495 + 492 WP_001301587.1 DUF1097 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - csgG / csgF / csgE / csgD / csgB / csgA / csgC 1395781..1408063 12282


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T51944 WP_000854914.1 NZ_CP010304:1397125-1397499 [Escherichia coli O157:H7 str. SS52]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T51944 NZ_CP010304:1397125-1397499 [Escherichia coli O157:H7 str. SS52]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13718.51 Da        Isoelectric Point: 6.6249

>AT51944 WP_001280954.1 NZ_CP010304:1396704-1397078 [Escherichia coli O157:H7 str. SS52]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT51944 NZ_CP010304:1396704-1397078 [Escherichia coli O157:H7 str. SS52]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0VS41

References