Detailed information of TA system TA051904

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2090228..2090527
• Replicon: chromosome
• Accession: NZ_CP010299
• Organism: Staphylococcus aureus strain ATCC BAA1680

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: RM27_RS14765
• Protein ID: WP_011447039.1
• Coordinates: 2090351..2090527 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2090228..2090283 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RM27_RS14740	2085559..2085819	+	261	WP_001791826.1	hypothetical protein	-
RM27_RS09720	2085872..2086222	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
RM27_RS09725	2086907..2087356	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
RM27_RS15430	2087451..2087786	-	336	Protein_2003	SH3 domain-containing protein	-
RM27_RS09735	2088436..2088927	-	492	WP_000919350.1	staphylokinase	-
RM27_RS09740	2089118..2089873	-	756	WP_000861038.1	CHAP domain-containing protein	-
RM27_RS09745	2089885..2090139	-	255	WP_000611512.1	phage holin	-
RM27_RS14760	2090191..2090298	+	108	WP_001791821.1	hypothetical protein	-
-	2090220..2090359	+	140	NuclAT_0	-	-
-	2090220..2090359	+	140	NuclAT_0	-	-
-	2090220..2090359	+	140	NuclAT_0	-	-
-	2090220..2090359	+	140	NuclAT_0	-	-
-	2090228..2090283	+	56	-	-	Antitoxin
RM27_RS14765	2090351..2090527	-	177	WP_011447039.1	putative holin-like toxin	Toxin
RM27_RS09755	2090677..2090973	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
RM27_RS09760	2091031..2091318	-	288	WP_001040261.1	hypothetical protein	-
RM27_RS14770	2091365..2091517	-	153	WP_001153681.1	hypothetical protein	-
RM27_RS09770	2091507..2095292	-	3786	WP_000582165.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2085872..2144839	58967

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T51904 WP_011447039.1 NZ_CP010299:c2090527-2090351 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T51904 NZ_CP010299:c2090527-2090351 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT51904 NZ_CP010299:2090228-2090283 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin