Detailed information of TA system TA051888

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2090214..2090513
• Replicon: chromosome
• Accession: NZ_CP010298
• Organism: Staphylococcus aureus strain ATCC BAA1680

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: RM31_RS14765
• Protein ID: WP_011447039.1
• Coordinates: 2090337..2090513 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2090214..2090269 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RM31_RS14740	2085545..2085805	+	261	WP_001791826.1	hypothetical protein	-
RM31_RS09725	2085858..2086208	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
RM31_RS09730	2086893..2087342	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
RM31_RS15420	2087437..2087772	-	336	Protein_2003	SH3 domain-containing protein	-
RM31_RS09740	2088422..2088913	-	492	WP_000919350.1	staphylokinase	-
RM31_RS09745	2089104..2089859	-	756	WP_000861038.1	CHAP domain-containing protein	-
RM31_RS09750	2089871..2090125	-	255	WP_000611512.1	phage holin	-
RM31_RS14760	2090177..2090284	+	108	WP_001791821.1	hypothetical protein	-
-	2090206..2090345	+	140	NuclAT_0	-	-
-	2090206..2090345	+	140	NuclAT_0	-	-
-	2090206..2090345	+	140	NuclAT_0	-	-
-	2090206..2090345	+	140	NuclAT_0	-	-
-	2090214..2090269	+	56	-	-	Antitoxin
RM31_RS14765	2090337..2090513	-	177	WP_011447039.1	putative holin-like toxin	Toxin
RM31_RS09760	2090663..2090959	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
RM31_RS09765	2091017..2091304	-	288	WP_001040261.1	hypothetical protein	-
RM31_RS14770	2091351..2091503	-	153	WP_001153681.1	hypothetical protein	-
RM31_RS09775	2091493..2095278	-	3786	WP_000582165.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	map / hlb / scn / chp / sak / hlb / groEL	2082042..2144825	62783

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T51888 WP_011447039.1 NZ_CP010298:c2090513-2090337 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T51888 NZ_CP010298:c2090513-2090337 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT51888 NZ_CP010298:2090214-2090269 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin