Detailed information of TA system TA051872

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2090215..2090514
• Replicon: chromosome
• Accession: NZ_CP010297
• Organism: Staphylococcus aureus strain ATCC BAA1680

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: QT38_RS14750
• Protein ID: WP_011447039.1
• Coordinates: 2090338..2090514 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2090215..2090270 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QT38_RS14725	2085546..2085806	+	261	WP_001791826.1	hypothetical protein	-
QT38_RS09725	2085859..2086209	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
QT38_RS09730	2086894..2087343	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
QT38_RS15420	2087438..2087773	-	336	Protein_2002	SH3 domain-containing protein	-
QT38_RS09740	2088423..2088914	-	492	WP_000919350.1	staphylokinase	-
QT38_RS09745	2089105..2089860	-	756	WP_000861038.1	CHAP domain-containing protein	-
QT38_RS09750	2089872..2090126	-	255	WP_000611512.1	phage holin	-
QT38_RS14745	2090178..2090285	+	108	WP_001791821.1	hypothetical protein	-
-	2090207..2090346	+	140	NuclAT_0	-	-
-	2090207..2090346	+	140	NuclAT_0	-	-
-	2090207..2090346	+	140	NuclAT_0	-	-
-	2090207..2090346	+	140	NuclAT_0	-	-
-	2090215..2090270	+	56	-	-	Antitoxin
QT38_RS14750	2090338..2090514	-	177	WP_011447039.1	putative holin-like toxin	Toxin
QT38_RS09760	2090664..2090960	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
QT38_RS09765	2091018..2091305	-	288	WP_001040261.1	hypothetical protein	-
QT38_RS14755	2091352..2091504	-	153	WP_001153681.1	hypothetical protein	-
QT38_RS09775	2091494..2095279	-	3786	WP_000582165.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2085859..2144826	58967

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T51872 WP_011447039.1 NZ_CP010297:c2090514-2090338 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T51872 NZ_CP010297:c2090514-2090338 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT51872 NZ_CP010297:2090215-2090270 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin