Detailed information of TA system TA051849

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2555430..2555614
• Replicon: chromosome
• Accession: NZ_CP010295
• Organism: Staphylococcus aureus strain ATCC BAA1680

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: Q2FVI9
• Locus tag: RM29_RS15055
• Protein ID: WP_000482650.1
• Coordinates: 2555507..2555614 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2555430..2555490 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RM29_RS15035	2550960..2551127	-	168	WP_001790576.1	hypothetical protein	-
RM29_RS12100	2551358..2553091	-	1734	WP_000486494.1	ABC transporter ATP-binding protein/permease	-
RM29_RS12105	2553116..2554879	-	1764	WP_001064838.1	ABC transporter ATP-binding protein/permease	-
-	2555430..2555490	+	61	-	-	Antitoxin
RM29_RS15055	2555507..2555614	-	108	WP_000482650.1	type I toxin-antitoxin system Fst family toxin	Toxin
RM29_RS12110	2555748..2556134	-	387	WP_000779358.1	flippase GtxA	-
RM29_RS12115	2556402..2557544	+	1143	WP_001176863.1	glycerate kinase	-
RM29_RS12120	2557604..2558263	+	660	WP_000831298.1	membrane protein	-
RM29_RS12125	2558445..2559656	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
RM29_RS12130	2559779..2560252	-	474	WP_000456489.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (7-103)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T51849 WP_000482650.1 NZ_CP010295:c2555614-2555507 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T51849 NZ_CP010295:c2555614-2555507 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT51849 NZ_CP010295:2555430-2555490 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2C9TTS8

Antitoxin