Detailed information of TA system TA051785

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 2185729..2186423
• Replicon: chromosome
• Accession: NZ_CP010247
• Organism: Yersinia pestis Pestoides G

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: A0A0E1NW62
• Locus tag: CH43_RS10455
• Protein ID: WP_002214787.1
• Coordinates: 2185729..2186025 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q666X1
• Locus tag: CH43_RS10460
• Protein ID: WP_002209924.1
• Coordinates: 2186025..2186423 (+)
• Length: 133 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CH43_RS10420	2180851..2182368	+	1518	WP_002209930.1	lysine--tRNA ligase	-
CH43_RS10430	2182801..2184015	+	1215	WP_011906175.1	tyrosine-type recombinase/integrase	-
CH43_RS10435	2184097..2184282	-	186	WP_002209928.1	hypothetical protein	-
CH43_RS10445	2184880..2185140	+	261	WP_002214785.1	type II toxin-antitoxin system RelE/ParE family toxin	-
CH43_RS10450	2185203..2185565	+	363	WP_002209925.1	helix-turn-helix domain-containing protein	-
CH43_RS10455	2185729..2186025	+	297	WP_002214787.1	type II toxin-antitoxin system MqsR family toxin	Toxin
CH43_RS10460	2186025..2186423	+	399	WP_002209924.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
CH43_RS10465	2186823..2189114	-	2292	WP_002209923.1	toprim domain-containing protein	-
CH43_RS10470	2189414..2189740	+	327	WP_002209922.1	type II toxin-antitoxin system RelE/ParE family toxin	-
CH43_RS24635	2189733..2189885	+	153	WP_002209921.1	hypothetical protein	-
CH43_RS10480	2189899..2190099	-	201	WP_002209920.1	AlpA family transcriptional regulator	-
CH43_RS10485	2190281..2190613	-	333	WP_002214791.1	hypothetical protein	-
CH43_RS10490	2190619..2190855	-	237	WP_002214792.1	hypothetical protein	-
CH43_RS10495	2190868..2191233	-	366	WP_002209919.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Cro/C1-type helix-turn-helix domain (75-128)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11319.12 Da
• Isoelectric Point: 7.8810

>T51785 WP_002214787.1 NZ_CP010247:2185729-2186025 [Yersinia pestis Pestoides G]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLNVSFKEI

Nucleotide

• Length: 297 bp

>T51785 NZ_CP010247:2185729-2186025 [Yersinia pestis Pestoides G]
ATGGAGAAACGGACTCCGCATACTCGTTTATTAAAAGTAAAAGAATTGGTATTGAAGGGGAATATTAAAACGACACGAAC
TGCCAGAGATGGGGCTGAGGAACTGGGACTGAGTTTTAGAGATATGTGTGATGCAGTTTCCGAACTGATTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACCATTTGGCAGGATGTTTACCGTCCTATGCTTTCTTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGAATGTCTCGTTTAAGGAGATTTAA

Antitoxin

Protein

• Length: 133 a.a.
• Molecular weight: 14657.17 Da
• Isoelectric Point: 8.4923

>AT51785 WP_002209924.1 NZ_CP010247:2186025-2186423 [Yersinia pestis Pestoides G]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Nucleotide

• Length: 399 bp

>AT51785 NZ_CP010247:2186025-2186423 [Yersinia pestis Pestoides G]
ATGATGAAATGTCCAGTTTGTGGCGGTGTAGAATTAATCCACGAAGCGCGTGACGTTCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGGCAACATTGCCCGGCATGCGGTGAAACAGTCATGACCGAAGCCGAGTCCGATGTCT
ATGCAGCAAAAACAATGCTTTTGCGAAAAATGGTCAATACAGAATCGATTGCCCCCGCATATATTGTGCAGATCCGAAAA
AAGTTGGGCCTAAACCAGCGGGAAGCCAGTGAGATTTTTGGTGGTGGGGTTAATGCATTTTCGCGTTACGAAAAAGGTAA
GGCTTTGCCACATCCATCAACGATAAAACTGTTGCAAGTGCTTGATAAACACCCGGAGTTATTGAATGAAATTAGGTAG

Structures

Toxin

• AlphaFold DB: A0A0E1NW62

Antitoxin

• AlphaFold DB: Q666X1