Detailed information of TA system TA051471

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 1373233..1373604
• Replicon: chromosome
• Accession: NZ_CP010221
• Organism: Escherichia coli strain M19

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: A0A891STD1
• Locus tag: RG63_RS07015
• Protein ID: WP_042853000.1
• Coordinates: 1373410..1373604 (-)
• Length: 65 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	1373233..1373411 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RG63_RS06970	1368675..1369331	-	657	WP_000011652.1	carbon-nitrogen hydrolase family protein	-
RG63_RS06975	1369433..1369663	-	231	WP_000916763.1	DNA polymerase III subunit theta	-
RG63_RS06980	1369802..1370176	+	375	WP_000204699.1	CopC domain-containing protein YobA	-
RG63_RS06985	1370180..1371052	+	873	WP_000879280.1	copper homeostasis membrane protein CopD	-
RG63_RS06990	1371065..1371406	+	342	WP_000976492.1	YebY family protein	-
RG63_RS07000	1371799..1372875	-	1077	WP_001189091.1	phage integrase Arm DNA-binding domain-containing protein	-
RG63_RS07005	1372841..1373122	-	282	WP_001311878.1	excisionase	-
RG63_RS07010	1373229..1373417	-	189	WP_001356607.1	DUF1187 family protein	-
-	1373233..1373411	+	179	NuclAT_0	-	Antitoxin
-	1373233..1373411	+	179	NuclAT_0	-	Antitoxin
-	1373233..1373411	+	179	NuclAT_0	-	Antitoxin
-	1373233..1373411	+	179	NuclAT_0	-	Antitoxin
RG63_RS07015	1373410..1373604	-	195	WP_042853000.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
RG63_RS07020	1373661..1374470	-	810	WP_000166317.1	recombination protein RecT	-
RG63_RS07025	1374463..1377096	-	2634	WP_021527613.1	exodeoxyribonuclease VIII	-
RG63_RS07030	1377195..1377470	-	276	WP_001452559.1	hypothetical protein	-
RG63_RS07035	1377545..1377721	-	177	WP_000245528.1	hypothetical protein	-
RG63_RS07040	1377715..1377936	-	222	WP_073519610.1	cell division protein FtsZ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1365932..1427186	61254

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-54)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7019.87 Da
• Isoelectric Point: 8.6419

>T51471 WP_042853000.1 NZ_CP010221:c1373604-1373410 [Escherichia coli]
MRYDDVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Nucleotide

• Length: 195 bp

>T51471 NZ_CP010221:c1373604-1373410 [Escherichia coli]
ATGAGATATGACGATGTTAAACCATGTCCGTTTTGTGGTTGTCCATCTGTTACGGTGAAAGCAATTTCAGGATATTACCG
GGCAAAATGCAACGGATGCGAATCCCGAACTGGCTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CTACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin

Nucleotide

• Length: 179 bp

>AT51471 NZ_CP010221:1373233-1373411 [Escherichia coli]
GAGGACAGAAGTTTCTCGCAATTAAAATTTATCAGCTTTACTTTCTGCTCTCTGGACACGCCTGCTTCTTTTTTCCCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAATTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCTTTTT
CAATAGTGGCAGTTATTTT

Structures

Antitoxin