Detailed information of TA system TA051401

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 2166946..2167317
• Replicon: chromosome
• Accession: NZ_CP010213
• Organism: Escherichia coli strain M15

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: A0A891STD1
• Locus tag: RG61_RS11190
• Protein ID: WP_042853000.1
• Coordinates: 2167123..2167317 (-)
• Length: 65 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	2166946..2167124 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RG61_RS11145	2162388..2163044	-	657	WP_000011652.1	carbon-nitrogen hydrolase family protein	-
RG61_RS11150	2163146..2163376	-	231	WP_000916763.1	DNA polymerase III subunit theta	-
RG61_RS11155	2163515..2163889	+	375	WP_000204699.1	CopC domain-containing protein YobA	-
RG61_RS11160	2163893..2164765	+	873	WP_000879280.1	copper homeostasis membrane protein CopD	-
RG61_RS11165	2164778..2165119	+	342	WP_000976492.1	YebY family protein	-
RG61_RS11175	2165512..2166588	-	1077	WP_001189091.1	phage integrase Arm DNA-binding domain-containing protein	-
RG61_RS11180	2166554..2166835	-	282	WP_001311878.1	excisionase	-
RG61_RS11185	2166942..2167130	-	189	WP_001356607.1	DUF1187 family protein	-
-	2166946..2167124	+	179	NuclAT_0	-	Antitoxin
-	2166946..2167124	+	179	NuclAT_0	-	Antitoxin
-	2166946..2167124	+	179	NuclAT_0	-	Antitoxin
-	2166946..2167124	+	179	NuclAT_0	-	Antitoxin
RG61_RS11190	2167123..2167317	-	195	WP_042853000.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
RG61_RS11195	2167374..2168183	-	810	WP_000166317.1	recombination protein RecT	-
RG61_RS11200	2168176..2170809	-	2634	WP_021527613.1	exodeoxyribonuclease VIII	-
RG61_RS11205	2170908..2171183	-	276	WP_001452559.1	hypothetical protein	-
RG61_RS11210	2171258..2171428	-	171	WP_001359121.1	hypothetical protein	-
RG61_RS11215	2171428..2171649	-	222	WP_073519610.1	cell division protein FtsZ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2157738..2231182	73444

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-54)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7019.87 Da
• Isoelectric Point: 8.6419

>T51401 WP_042853000.1 NZ_CP010213:c2167317-2167123 [Escherichia coli]
MRYDDVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Nucleotide

• Length: 195 bp

>T51401 NZ_CP010213:c2167317-2167123 [Escherichia coli]
ATGAGATATGACGATGTTAAACCATGTCCGTTTTGTGGTTGTCCATCTGTTACGGTGAAAGCAATTTCAGGATATTACCG
GGCAAAATGCAACGGATGCGAATCCCGAACTGGCTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CTACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin

Nucleotide

• Length: 179 bp

>AT51401 NZ_CP010213:2166946-2167124 [Escherichia coli]
GAGGACAGAAGTTTCTCGCAATTAAAATTTATCAGCTTTACTTTCTGCTCTCTGGACACGCCTGCTTCTTTTTTCCCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAATTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCTTTTT
CAATAGTGGCAGTTATTTT

Structures

Antitoxin