Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | ralRA/- |
Location | 177271..177630 | Replicon | chromosome |
Accession | NZ_CP010180 | ||
Organism | Escherichia coli strain M1 |
Toxin (Protein)
Gene name | ralR | Uniprot ID | F4VC37 |
Locus tag | RG54_RS00950 | Protein ID | WP_001317028.1 |
Coordinates | 177436..177630 (-) | Length | 65 a.a. |
Antitoxin (RNA)
Gene name | ralA | ||
Locus tag | - | ||
Coordinates | 177271..177437 (+) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
RG54_RS00925 | 173226..174599 | + | 1374 | WP_000123739.1 | ATP-dependent RNA helicase DbpA | - |
RG54_RS00930 | 174728..175663 | - | 936 | WP_053264959.1 | tRNA 2-thiocytidine(32) synthetase TtcA | - |
RG54_RS00935 | 175715..176950 | - | 1236 | WP_000040852.1 | site-specific integrase | - |
RG54_RS00940 | 176952..177167 | - | 216 | WP_000079604.1 | excisionase XisR | - |
RG54_RS00945 | 177246..177443 | - | 198 | WP_024170988.1 | DUF1187 family protein | - |
- | 177271..177437 | + | 167 | NuclAT_1 | - | Antitoxin |
- | 177271..177437 | + | 167 | NuclAT_1 | - | Antitoxin |
- | 177271..177437 | + | 167 | NuclAT_1 | - | Antitoxin |
- | 177271..177437 | + | 167 | NuclAT_1 | - | Antitoxin |
RG54_RS00950 | 177436..177630 | - | 195 | WP_001317028.1 | type I toxin-antitoxin system endodeoxyribonuclease toxin RalR | Toxin |
RG54_RS00955 | 177687..178496 | - | 810 | WP_000166319.1 | recombination protein RecT | - |
RG54_RS00960 | 178489..181089 | - | 2601 | WP_000105136.1 | exodeoxyribonuclease VIII | - |
RG54_RS00965 | 181191..181466 | - | 276 | WP_024251429.1 | hypothetical protein | - |
RG54_RS00970 | 181541..181711 | - | 171 | WP_001352098.1 | conserved protein, Rac prophage | - |
RG54_RS00975 | 181711..181932 | - | 222 | WP_000560224.1 | killing protein KilR | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | - | 175715..224812 | 49097 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 65 a.a. Molecular weight: 7018.89 Da Isoelectric Point: 8.9538
>T51183 WP_001317028.1 NZ_CP010180:c177630-177436 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV
Download Length: 195 bp
>T51183 NZ_CP010180:c177630-177436 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA
Antitoxin
Download Length: 167 bp
>AT51183 NZ_CP010180:177271-177437 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAATTTTACCTGAGAGCATTTTTTC
GCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTTCAATAGTGGCGG
TAATTTT
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAATTTTACCTGAGAGCATTTTTTC
GCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTTCAATAGTGGCGG
TAATTTT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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