Detailed information of TA system TA051109

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 1219380..1219751
• Replicon: chromosome
• Accession: NZ_CP010176
• Organism: Escherichia coli strain H10

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: F4VC37
• Locus tag: RG51_RS06365
• Protein ID: WP_001317028.1
• Coordinates: 1219557..1219751 (-)
• Length: 65 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	1219380..1219558 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RG51_RS06340	1215335..1216708	+	1374	WP_000123745.1	ATP-dependent RNA helicase DbpA	-
RG51_RS06345	1216837..1217772	-	936	WP_001157407.1	tRNA 2-thiocytidine(32) synthetase TtcA	-
RG51_RS06350	1217824..1219059	-	1236	WP_000040858.1	site-specific integrase	-
RG51_RS06355	1219061..1219276	-	216	WP_000079604.1	excisionase XisR	-
RG51_RS06360	1219355..1219564	-	210	WP_021565074.1	double-strand break reduction protein RcbA	-
-	1219380..1219558	+	179	NuclAT_0	-	Antitoxin
-	1219380..1219558	+	179	NuclAT_0	-	Antitoxin
-	1219380..1219558	+	179	NuclAT_0	-	Antitoxin
-	1219380..1219558	+	179	NuclAT_0	-	Antitoxin
RG51_RS06365	1219557..1219751	-	195	WP_001317028.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
RG51_RS06370	1219808..1220617	-	810	WP_000166319.1	recombination protein RecT	-
RG51_RS06375	1220610..1223210	-	2601	WP_021565075.1	exodeoxyribonuclease VIII	-
RG51_RS06380	1223312..1223587	-	276	WP_073470675.1	hypothetical protein	-
RG51_RS06385	1223662..1223832	-	171	WP_001352098.1	conserved protein, Rac prophage	-
RG51_RS06390	1223832..1224053	-	222	WP_000560223.1	killing protein KilR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1215335..1265071	49736

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-54)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7018.89 Da
• Isoelectric Point: 8.9538

>T51109 WP_001317028.1 NZ_CP010176:c1219751-1219557 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Nucleotide

• Length: 195 bp

>T51109 NZ_CP010176:c1219751-1219557 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin

Nucleotide

• Length: 179 bp

>AT51109 NZ_CP010176:1219380-1219558 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGAAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Structures

Toxin

• AlphaFold DB: A0A7L6LHV7

Antitoxin