Detailed information of TA system TA051038

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): prlF-yhaV (relBE)/YhaV-PrlF
• Location: 795217..796016
• Replicon: chromosome
• Accession: NZ_CP010170
• Organism: Escherichia coli strain H6

Toxin (Protein)

• Gene name: yhaV
• Uniprot ID: -
• Locus tag: RG48_RS04155
• Protein ID: WP_073464266.1
• Coordinates: 795217..795681 (-)
• Length: 155 a.a.

Antitoxin (Protein)

• Gene name: prlF
• Uniprot ID: D6JF08
• Locus tag: RG48_RS04160
• Protein ID: WP_001308975.1
• Coordinates: 795681..796016 (-)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RG48_RS04120	790218..790652	-	435	WP_000948824.1	PTS sugar transporter subunit IIA	-
RG48_RS04125	790670..791548	-	879	WP_073464261.1	PTS system mannose/fructose/sorbose family transporter subunit IID	-
RG48_RS04130	791538..792317	-	780	WP_000406214.1	PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC	-
RG48_RS04135	792328..792801	-	474	WP_073464263.1	PTS N-acetylgalactosamine transporter subunit IIB	-
RG48_RS04140	792824..794104	-	1281	WP_000681920.1	tagatose-bisphosphate aldolase subunit KbaZ	-
RG48_RS04150	794353..795162	+	810	WP_000072187.1	aga operon transcriptional regulator AgaR	-
RG48_RS04155	795217..795681	-	465	WP_073464266.1	type II toxin-antitoxin system ribonuclease toxin YhaV	Toxin
RG48_RS04160	795681..796016	-	336	WP_001308975.1	type II toxin-antitoxin system antitoxin PrlF	Antitoxin
RG48_RS04165	796165..797736	-	1572	WP_032181387.1	galactarate dehydratase	-
RG48_RS04170	798111..799445	+	1335	WP_000599636.1	galactarate/glucarate/glycerate transporter GarP	-
RG48_RS04175	799461..800231	+	771	WP_001058209.1	2-dehydro-3-deoxyglucarate aldolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin endonuclease, YhaV (12-150)

Antitoxin

• PrlF antitoxin (14-110)

Sequences

Toxin

Protein

• Length: 155 a.a.
• Molecular weight: 17754.10 Da
• Isoelectric Point: 9.4944

>T51038 WP_073464266.1 NZ_CP010170:c795681-795217 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEENITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Nucleotide

• Length: 465 bp

>T51038 NZ_CP010170:c795681-795217 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGAATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12343.97 Da
• Isoelectric Point: 4.8616

>AT51038 WP_001308975.1 NZ_CP010170:c796016-795681 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Nucleotide

• Length: 336 bp

>AT51038 NZ_CP010170:c796016-795681 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Structures

Antitoxin

• AlphaFold DB: D6JF08