Detailed information of TA system TA050872

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 3267180..3267589
• Replicon: chromosome
• Accession: NZ_CP010151
• Organism: Escherichia coli strain D8

Toxin (Protein)

• Gene name: symE
• Uniprot ID: -
• Locus tag: RG41_RS16900
• Protein ID: WP_001534835.1
• Coordinates: 3267251..3267589 (+)
• Length: 113 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	3267180..3267256 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RG41_RS16890	3262368..3263678	+	1311	WP_001534837.1	restriction endonuclease subunit S	-
RG41_RS16895	3263773..3267036	+	3264	WP_001534836.1	type I restriction endonuclease subunit R	-
-	3267180..3267256	-	77	NuclAT_12	-	Antitoxin
-	3267180..3267256	-	77	NuclAT_12	-	Antitoxin
-	3267180..3267256	-	77	NuclAT_12	-	Antitoxin
-	3267180..3267256	-	77	NuclAT_12	-	Antitoxin
-	3267180..3267256	-	77	NuclAT_13	-	Antitoxin
-	3267180..3267256	-	77	NuclAT_13	-	Antitoxin
-	3267180..3267256	-	77	NuclAT_13	-	Antitoxin
-	3267180..3267256	-	77	NuclAT_13	-	Antitoxin
RG41_RS16900	3267251..3267589	+	339	WP_001534835.1	endoribonuclease SymE	Toxin
RG41_RS16905	3267631..3267795	-	165	Protein_3048	DUF1127 domain-containing protein	-
RG41_RS16910	3267973..3268143	+	171	WP_000199350.1	GntR family transcriptional regulator	-
RG41_RS16915	3268273..3269193	-	921	WP_000181193.1	Rpn family recombination-promoting nuclease/putative transposase	-
RG41_RS16920	3269378..3270658	+	1281	WP_001535800.1	DUF445 domain-containing protein	-
RG41_RS16925	3270774..3271925	+	1152	WP_001338076.1	2-hydroxyacyl-CoA dehydratase subunit D	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 113 a.a.
• Molecular weight: 12310.04 Da
• Isoelectric Point: 7.8226

>T50872 WP_001534835.1 NZ_CP010151:3267251-3267589 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYNRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQDFIGVISNKTPR

Nucleotide

• Length: 339 bp

>T50872 NZ_CP010151:3267251-3267589 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGGATTACAACCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAAGAGAGCGAA
CTGATGCAGTCACTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAAGCAGGTGCAGGATTTTATTGGGGTGATTAG
TAACAAAACGCCACGCTAA

Antitoxin

Nucleotide

• Length: 77 bp

>AT50872 NZ_CP010151:c3267256-3267180 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Antitoxin