Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3189166..3189424 Replicon chromosome
Accession NZ_CP010151
Organism Escherichia coli strain D8

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag RG41_RS16495 Protein ID WP_000809168.1
Coordinates 3189272..3189424 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 3189166..3189223 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RG41_RS16475 3184995..3186254 - 1260 WP_000494928.1 hypothetical protein -
RG41_RS16480 3186383..3187876 - 1494 WP_001468392.1 sulfatase-like hydrolase/transferase -
RG41_RS16485 3187896..3188657 - 762 WP_001274832.1 hypothetical protein -
- 3189166..3189223 - 58 - - Antitoxin
RG41_RS16495 3189272..3189424 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
RG41_RS16500 3189529..3190659 - 1131 WP_001118464.1 molecular chaperone DnaJ -
RG41_RS16505 3190748..3192664 - 1917 WP_000516135.1 molecular chaperone DnaK -
RG41_RS16510 3193037..3193441 + 405 WP_000843687.1 DUF2541 family protein -
RG41_RS16515 3193467..3194180 + 714 WP_001102393.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T50869 WP_000809168.1 NZ_CP010151:3189272-3189424 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T50869 NZ_CP010151:3189272-3189424 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT50869 NZ_CP010151:c3189223-3189166 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References