Detailed information of TA system TA050765

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 605971..606191
• Replicon: chromosome
• Accession: NZ_CP010145
• Organism: Escherichia coli strain D5

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: J7R083
• Locus tag: RG38_RS03265
• Protein ID: WP_000170963.1
• Coordinates: 605971..606078 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	606125..606191 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RG38_RS03240	601815..602897	+	1083	WP_000804726.1	peptide chain release factor 1	-
RG38_RS03245	602897..603730	+	834	WP_000456467.1	peptide chain release factor N(5)-glutamine methyltransferase	-
RG38_RS03250	603727..604119	+	393	WP_000200392.1	invasion regulator SirB2	-
RG38_RS03255	604123..604932	+	810	WP_001257044.1	invasion regulator SirB1	-
RG38_RS03260	604968..605822	+	855	WP_000811065.1	3-deoxy-8-phosphooctulonate synthase	-
RG38_RS03265	605971..606078	-	108	WP_000170963.1	small toxic polypeptide LdrB	Toxin
-	606125..606191	+	67	-	-	Antitoxin
RG38_RS03275	606483..607583	-	1101	WP_001295620.1	sodium-potassium/proton antiporter ChaA	-
RG38_RS03280	607853..608083	+	231	WP_001146442.1	putative cation transport regulator ChaB	-
RG38_RS03285	608241..608936	+	696	WP_001297117.1	glutathione-specific gamma-glutamylcyclotransferase	-
RG38_RS03290	608980..609333	-	354	WP_001169669.1	DsrE/F sulfur relay family protein YchN	-
RG38_RS03295	609518..610912	+	1395	WP_000086201.1	inverse autotransporter invasin YchO	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3971.74 Da
• Isoelectric Point: 11.4779

>T50765 WP_000170963.1 NZ_CP010145:c606078-605971 [Escherichia coli]
MTLAQFAMTFWHDLAAPILAGIITAAIVGWWRNRK

Nucleotide

• Length: 108 bp

>T50765 NZ_CP010145:c606078-605971 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Nucleotide

• Length: 67 bp

>AT50765 NZ_CP010145:606125-606191 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Structures

Antitoxin