Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 2804880..2805137 Replicon chromosome
Accession NZ_CP010134
Organism Escherichia coli strain D1

Toxin (Protein)


Gene name hokA Uniprot ID V0YDF1
Locus tag RG34_RS14560 Protein ID WP_001135738.1
Coordinates 2804985..2805137 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokA
Locus tag -
Coordinates 2804880..2804934 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RG34_RS14540 2800105..2801100 - 996 WP_001182653.1 O-acetyltransferase WecH -
RG34_RS14545 2801275..2801574 + 300 WP_000980104.1 membrane protein -
RG34_RS14550 2801669..2802580 + 912 WP_001168544.1 glycine--tRNA ligase subunit alpha -
RG34_RS14555 2802590..2804659 + 2070 WP_001291774.1 glycine--tRNA ligase subunit beta -
- 2804880..2804934 - 55 - - Antitoxin
RG34_RS14560 2804985..2805137 + 153 WP_001135738.1 type I toxin-antitoxin system toxin HokA Toxin
RG34_RS29260 2805126..2805185 - 60 WP_212591412.1 hypothetical protein -
RG34_RS14565 2805325..2805537 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
RG34_RS14570 2805818..2806108 - 291 WP_000455798.1 HTH-type transcriptional regulator -
RG34_RS14575 2806542..2807252 + 711 WP_000190516.1 DUF3053 domain-containing protein -
RG34_RS14580 2807302..2808276 - 975 WP_000805027.1 glyoxylate/hydroxypyruvate reductase GhrB -
RG34_RS14585 2808380..2809039 - 660 WP_000747625.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(5-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5912.14 Da        Isoelectric Point: 7.7173

>T50651 WP_001135738.1 NZ_CP010134:2804985-2805137 [Escherichia coli]
MPQKYRLLSLIVICFTLLFFTWMIRDSLCELHIKQGSYELAAFLACNLKE

Download         Length: 153 bp

>T50651 NZ_CP010134:2804985-2805137 [Escherichia coli]
ATGCCGCAGAAATATAGATTACTTTCTTTAATAGTGATTTGTTTCACGCTTTTATTTTTCACCTGGATGATAAGAGATTC
ACTGTGTGAATTGCATATTAAACAGGGGAGTTATGAGCTGGCGGCATTTTTAGCCTGCAATTTAAAAGAGTAA

Antitoxin


Download         Length: 55 bp

>AT50651 NZ_CP010134:c2804934-2804880 [Escherichia coli]
GTTCAGGCATAGGGTAGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LX93

Antitoxin

Download structure file

References