Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 1856429..1856687 Replicon chromosome
Accession NZ_CP010134
Organism Escherichia coli strain D1

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag RG34_RS09630 Protein ID WP_000809168.1
Coordinates 1856535..1856687 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 1856429..1856486 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RG34_RS09605 1851454..1852806 + 1353 Protein_1719 fimbria/pilus outer membrane usher protein -
RG34_RS28620 1852819..1853779 + 961 Protein_1720 fimbrial family protein -
RG34_RS09620 1853818..1854717 - 900 WP_001300855.1 transcriptional activator NhaR -
RG34_RS09625 1854783..1855949 - 1167 WP_073514610.1 Na+/H+ antiporter NhaA -
- 1856429..1856486 - 58 - - Antitoxin
RG34_RS09630 1856535..1856687 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
RG34_RS09635 1856791..1857921 - 1131 WP_001118464.1 molecular chaperone DnaJ -
RG34_RS09640 1858010..1859926 - 1917 WP_000516135.1 molecular chaperone DnaK -
RG34_RS09645 1860303..1860707 + 405 WP_000843559.1 DUF2541 family protein -
RG34_RS09650 1860733..1861446 + 714 WP_001102379.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T50647 WP_000809168.1 NZ_CP010134:1856535-1856687 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T50647 NZ_CP010134:1856535-1856687 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTAGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT50647 NZ_CP010134:c1856486-1856429 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATAGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References