Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 4434036..4434538 Replicon chromosome
Accession NZ_CP010133
Organism Escherichia coli strain C11

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag RG33_RS22785 Protein ID WP_000767829.1
Coordinates 4434284..4434538 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag RG33_RS22780 Protein ID WP_001259255.1
Coordinates 4434036..4434287 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RG33_RS22750 4429214..4430281 - 1068 WP_000080102.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
RG33_RS22755 4430281..4431351 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
RG33_RS22760 4431348..4432652 - 1305 WP_001542955.1 histidinol dehydrogenase -
RG33_RS22765 4432658..4433557 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
RG33_RS22775 4433703..4433753 - 51 WP_001364200.1 his operon leader peptide -
RG33_RS22780 4434036..4434287 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
RG33_RS22785 4434284..4434538 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
RG33_RS22790 4434621..4435445 + 825 WP_000754758.1 SDR family oxidoreductase -
RG33_RS22795 4435491..4436420 + 930 WP_000803351.1 LysR family transcriptional regulator -
RG33_RS28960 4436635..4436697 + 63 WP_010723108.1 membrane protein YoeI -
RG33_RS22800 4436687..4438045 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
RG33_RS22805 4438224..4439282 + 1059 WP_000492346.1 transport protein YeeE -
RG33_RS22810 4439296..4439523 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T50629 WP_000767829.1 NZ_CP010133:4434284-4434538 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T50629 NZ_CP010133:4434284-4434538 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT50629 WP_001259255.1 NZ_CP010133:4434036-4434287 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT50629 NZ_CP010133:4434036-4434287 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References