Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2182949..2183451 Replicon chromosome
Accession NZ_CP010121
Organism Escherichia coli strain C4

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag RG27_RS10985 Protein ID WP_000767836.1
Coordinates 2183197..2183451 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag RG27_RS10980 Protein ID WP_001259255.1
Coordinates 2182949..2183200 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RG27_RS10950 2178126..2179193 - 1068 WP_073461858.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
RG27_RS10955 2179193..2180263 - 1071 WP_000108927.1 histidinol-phosphate transaminase -
RG27_RS10960 2180260..2181564 - 1305 WP_001306412.1 histidinol dehydrogenase -
RG27_RS10965 2181570..2182469 - 900 WP_000131789.1 ATP phosphoribosyltransferase -
RG27_RS10975 2182615..2182665 - 51 WP_001364200.1 his operon leader peptide -
RG27_RS10980 2182949..2183200 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
RG27_RS10985 2183197..2183451 + 255 WP_000767836.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
RG27_RS10990 2183534..2184358 + 825 WP_000754757.1 SDR family oxidoreductase -
RG27_RS10995 2184404..2185333 + 930 WP_000803351.1 LysR family transcriptional regulator -
RG27_RS26205 2185548..2185610 + 63 WP_010723108.1 membrane protein YoeI -
RG27_RS11000 2185600..2186958 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10181.65 Da        Isoelectric Point: 8.8560

>T50457 WP_000767836.1 NZ_CP010121:2183197-2183451 [Escherichia coli]
VKLIWSEESWDDYLYWQETNKRIVKKIIELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T50457 NZ_CP010121:2183197-2183451 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAGTCATGGGATGATTATCTGTACTGGCAGGAAACAAATAAGCGAATTGTTAAAAAGAT
CATTGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAGCATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT50457 WP_001259255.1 NZ_CP010121:2182949-2183200 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT50457 NZ_CP010121:2182949-2183200 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGCCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References