Detailed information of TA system TA050436

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 5038987..5039358
• Replicon: chromosome
• Accession: NZ_CP010119
• Organism: Escherichia coli strain C3

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: A0A839BBC2
• Locus tag: RG26_RS27170
• Protein ID: WP_021500490.1
• Coordinates: 5039164..5039358 (-)
• Length: 65 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	5038987..5039165 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RG26_RS27145	5034942..5036315	+	1374	WP_000123745.1	ATP-dependent RNA helicase DbpA	-
RG26_RS27150	5036444..5037379	-	936	WP_001157394.1	tRNA 2-thiocytidine(32) synthetase TtcA	-
RG26_RS27155	5037431..5038666	-	1236	WP_000040844.1	site-specific integrase	-
RG26_RS27160	5038668..5038883	-	216	WP_000079604.1	excisionase XisR	-
RG26_RS27165	5038983..5039171	-	189	WP_073519364.1	DUF1187 family protein	-
-	5038987..5039165	+	179	NuclAT_0	-	Antitoxin
-	5038987..5039165	+	179	NuclAT_0	-	Antitoxin
-	5038987..5039165	+	179	NuclAT_0	-	Antitoxin
-	5038987..5039165	+	179	NuclAT_0	-	Antitoxin
RG26_RS27170	5039164..5039358	-	195	WP_021500490.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
RG26_RS27175	5039422..5040510	-	1089	WP_063100796.1	recombinase RecT	-
RG26_RS27180	5040525..5043686	-	3162	WP_073519365.1	exodeoxyribonuclease VIII	-
RG26_RS27185	5043787..5044062	-	276	WP_073519366.1	hypothetical protein	-
RG26_RS27190	5044137..5044313	-	177	WP_000245533.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4972049..5086162	114113

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-54)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7046.98 Da
• Isoelectric Point: 9.2886

>T50436 WP_021500490.1 NZ_CP010119:c5039358-5039164 [Escherichia coli]
MRYEKVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Nucleotide

• Length: 195 bp

>T50436 NZ_CP010119:c5039358-5039164 [Escherichia coli]
ATGCGGTATGAAAAAGTCAAACCATGTCCGTTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
CGCAAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin

Nucleotide

• Length: 179 bp

>AT50436 NZ_CP010119:5038987-5039165 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTCCCTGA
GAGCATTTTTTCGCATTCCGATTTGGTTAACTTTGTTTTTGAGTACCTTGTCCAGCTGGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Structures

Toxin

• AlphaFold DB: A0A839BBC2

Antitoxin