Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 2291479..2292278 Replicon chromosome
Accession NZ_CP010119
Organism Escherichia coli strain C3

Toxin (Protein)


Gene name yhaV Uniprot ID U9XVR9
Locus tag RG26_RS11910 Protein ID WP_000347267.1
Coordinates 2291479..2291943 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag RG26_RS11915 Protein ID WP_001307405.1
Coordinates 2291943..2292278 (-) Length 112 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RG26_RS11875 2286480..2286914 - 435 WP_000948824.1 PTS sugar transporter subunit IIA -
RG26_RS11880 2286932..2287810 - 879 WP_001298758.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
RG26_RS11885 2287800..2288579 - 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
RG26_RS11890 2288590..2289063 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
RG26_RS11895 2289086..2290366 - 1281 WP_000681952.1 tagatose-bisphosphate aldolase subunit KbaZ -
RG26_RS11905 2290615..2291424 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
RG26_RS11910 2291479..2291943 - 465 WP_000347267.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
RG26_RS11915 2291943..2292278 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
RG26_RS11920 2292427..2293998 - 1572 WP_001273741.1 galactarate dehydratase -
RG26_RS11925 2294373..2295707 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
RG26_RS11930 2295723..2296493 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(12-150)

Antitoxin

(14-110)


Sequences


Toxin        


Download         Length: 155 a.a.        Molecular weight: 17807.17 Da        Isoelectric Point: 9.4947

>T50417 WP_000347267.1 NZ_CP010119:c2291943-2291479 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

>T50417 NZ_CP010119:c2291943-2291479 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT50417 WP_001307405.1 NZ_CP010119:c2292278-2291943 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT50417 NZ_CP010119:c2292278-2291943 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0E0XTR4


Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References