Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 4701716..4702515 Replicon chromosome
Accession NZ_CP010116
Organism Escherichia coli strain C1

Toxin (Protein)


Gene name yhaV Uniprot ID F0JQM9
Locus tag RC72_RS24210 Protein ID WP_000347270.1
Coordinates 4702051..4702515 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID A0A0V9H1L4
Locus tag RC72_RS24205 Protein ID WP_001551693.1
Coordinates 4701716..4702051 (+) Length 112 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RC72_RS24190 4697501..4698271 - 771 WP_072617374.1 2-dehydro-3-deoxyglucarate aldolase -
RC72_RS24195 4698287..4699621 - 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
RC72_RS24200 4699996..4701567 + 1572 WP_001273738.1 galactarate dehydratase -
RC72_RS24205 4701716..4702051 + 336 WP_001551693.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
RC72_RS24210 4702051..4702515 + 465 WP_000347270.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
RC72_RS24215 4702570..4703379 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
RC72_RS24225 4703628..4704908 + 1281 WP_001551694.1 tagatose-bisphosphate aldolase subunit KbaZ -
RC72_RS24230 4704931..4705404 + 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
RC72_RS24235 4705415..4706194 + 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
RC72_RS24240 4706184..4707062 + 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
RC72_RS24245 4707080..4707514 + 435 WP_000948837.1 PTS sugar transporter subunit IIA -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4692354..4702515 10161


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(12-150)

Antitoxin

(14-110)


Sequences


Toxin        


Download         Length: 155 a.a.        Molecular weight: 17806.22 Da        Isoelectric Point: 9.6924

>T50388 WP_000347270.1 NZ_CP010116:4702051-4702515 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEEAH

Download         Length: 465 bp

>T50388 NZ_CP010116:4702051-4702515 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTACAGCGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAGCCCATTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12347.87 Da        Isoelectric Point: 4.6890

>AT50388 WP_001551693.1 NZ_CP010116:4701716-4702051 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDTQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT50388 NZ_CP010116:4701716-4702051 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACACTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0V9NQ90


Antitoxin

Source ID Structure
AlphaFold DB A0A0V9H1L4

References