Detailed information of TA system TA050338

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 2811120..2811814
• Replicon: chromosome
• Accession: NZ_CP010067
• Organism: Yersinia pseudotuberculosis str. PA3606

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: BZ19_RS12785
• Protein ID: WP_024063131.1
• Coordinates: 2811518..2811814 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q666X1
• Locus tag: BZ19_RS12780
• Protein ID: WP_002209924.1
• Coordinates: 2811120..2811518 (-)
• Length: 133 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BZ19_RS12745	2806204..2806569	+	366	WP_002209919.1	hypothetical protein	-
BZ19_RS24240	2806582..2806815	+	234	Protein_2438	hypothetical protein	-
BZ19_RS24245	2806930..2807262	+	333	WP_038835201.1	hypothetical protein	-
BZ19_RS12760	2807444..2807644	+	201	WP_002209920.1	AlpA family transcriptional regulator	-
BZ19_RS24380	2807658..2807810	-	153	WP_002209921.1	hypothetical protein	-
BZ19_RS12770	2807803..2808129	-	327	WP_012303722.1	type II toxin-antitoxin system RelE/ParE family toxin	-
BZ19_RS12775	2808429..2810720	+	2292	WP_042659628.1	toprim domain-containing protein	-
BZ19_RS12780	2811120..2811518	-	399	WP_002209924.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
BZ19_RS12785	2811518..2811814	-	297	WP_024063131.1	type II toxin-antitoxin system MqsR family toxin	Toxin
BZ19_RS12790	2811978..2812340	-	363	WP_011192920.1	helix-turn-helix domain-containing protein	-
BZ19_RS12795	2812403..2812671	-	269	Protein_2447	type II toxin-antitoxin system RelE/ParE family toxin	-
BZ19_RS12805	2813269..2813454	+	186	WP_042659629.1	hypothetical protein	-
BZ19_RS12810	2813536..2814750	-	1215	WP_011192954.1	tyrosine-type recombinase/integrase	-
BZ19_RS12820	2815183..2816700	-	1518	WP_002209930.1	lysine--tRNA ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Cro/C1-type helix-turn-helix domain (75-128)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11318.17 Da
• Isoelectric Point: 7.8810

>T50338 WP_024063131.1 NZ_CP010067:c2811814-2811518 [Yersinia pseudotuberculosis str. PA3606]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLIVSFKEI

Nucleotide

• Length: 297 bp

>T50338 NZ_CP010067:c2811814-2811518 [Yersinia pseudotuberculosis str. PA3606]
ATGGAGAAACGGACTCCGCATACTCGTTTATTAAAAGTAAAAGAATTGGTATTGAAGGGGAATATTAAAACGACACGAAC
TGCCAGAGATGGGGCTGAGGAACTGGGACTGAGTTTTAGAGATATGTGTGATGCAGTTTCAGAACTGATTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACCATTTGGCAGGATGTTTACCGTCCTATGCTTTCTTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGATTGTCTCGTTTAAGGAGATTTAA

Antitoxin

Protein

• Length: 133 a.a.
• Molecular weight: 14657.17 Da
• Isoelectric Point: 8.4923

>AT50338 WP_002209924.1 NZ_CP010067:c2811518-2811120 [Yersinia pseudotuberculosis str. PA3606]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Nucleotide

• Length: 399 bp

>AT50338 NZ_CP010067:c2811518-2811120 [Yersinia pseudotuberculosis str. PA3606]
ATGATGAAATGTCCAGTTTGTGGCGGTGTAGAATTAATCCACGAAGCGCGTGACGTTCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGGCAACATTGCCCGGCATGCGGTGAAACAGTCATGACCGAAGCCGAGTCCGATGTCT
ATGCAGCAAAAACAATGCTTTTGCGAAAAATGGTCAATACAGAATCGATTGCCCCCGCATATATTGTGCAGATCCGAAAA
AAGTTGGGCCTAAACCAGCGGGAAGCCAGTGAGATTTTTGGTGGTGGGGTTAATGCATTTTCGCGTTACGAAAAAGGTAA
GGCTTTGCCACATCCATCAACGATAAAACTGTTGCAAGTGCTTGATAAACACCCGGAGTTATTGAATGAAATTAGGTAG

Structures

Antitoxin

• AlphaFold DB: Q666X1