Detailed information of TA system TA050296

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2678252..2678577
• Replicon: chromosome
• Accession: NZ_CP010052
• Organism: Bacillus subtilis subsp. subtilis str. 168

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: P54373
• Locus tag: QU35_RS13525
• Protein ID: WP_004398662.1
• Coordinates: 2678252..2678431 (+)
• Length: 60 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2678355..2678577 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QU35_RS21925	2677478..2677615	-	138	WP_003229934.1	hypothetical protein	-
QU35_RS13520	2677657..2678106	-	450	WP_003229933.1	phage portal protein	-
QU35_RS13525	2678252..2678431	+	180	WP_004398662.1	type I toxin-antitoxin system toxin TxpA	Toxin
-	2678355..2678577	-	223	NuclAT_0	-	Antitoxin
-	2678355..2678577	-	223	NuclAT_0	-	Antitoxin
-	2678355..2678577	-	223	NuclAT_0	-	Antitoxin
-	2678355..2678577	-	223	NuclAT_0	-	Antitoxin
QU35_RS22505	2678811..2678900	+	90	WP_075058862.1	type I toxin-antitoxin system toxin BsrH	-
QU35_RS13530	2679154..2679597	-	444	WP_003229930.1	phage tail tube protein	-
QU35_RS13535	2679600..2681000	-	1401	WP_003229929.1	phage tail sheath family protein	-
QU35_RS13540	2681001..2681192	-	192	WP_010886574.1	hypothetical protein	-
QU35_RS13545	2681189..2681626	-	438	WP_003229927.1	hypothetical protein	-
QU35_RS13550	2681639..2682142	-	504	WP_003246050.1	HK97 gp10 family phage protein	-
QU35_RS13555	2682139..2682501	-	363	WP_003229925.1	YqbH/XkdH family protein	-
QU35_RS13560	2682498..2682893	-	396	WP_004398566.1	DUF3199 family protein	-
QU35_RS13565	2682897..2683208	-	312	WP_003229923.1	YqbF domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2577221..2699255	122034

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (4-111)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6739.19 Da
• Isoelectric Point: 8.0370

>T50296 WP_004398662.1 NZ_CP010052:2678252-2678431 [Bacillus subtilis subsp. subtilis str. 168]
MSTYESLMVMIGFANLIGGIMTWVISLLTLLFMLRKKDTHPIYITVKEKCLHEDPPIKG

Nucleotide

• Length: 180 bp

>T50296 NZ_CP010052:2678252-2678431 [Bacillus subtilis subsp. subtilis str. 168]
ATGTCGACCTATGAATCTCTAATGGTCATGATCGGCTTTGCCAATTTAATAGGCGGGATTATGACATGGGTAATATCTCT
TTTAACATTATTATTCATGCTTAGAAAAAAAGACACTCATCCTATTTACATTACTGTAAAGGAAAAGTGTCTACACGAGG
ACCCTCCTATTAAAGGGTAG

Antitoxin

Nucleotide

• Length: 223 bp

>AT50296 NZ_CP010052:c2678577-2678355 [Bacillus subtilis subsp. subtilis str. 168]
CAAGCAAAAGTATTGCAACTACTGGCGTAAGCTTATAGTTGGTACCACATTACCACATTACCACTTGTTAATGTGTGTTA
CTTTCATGAGAAATGCTAAAATATAAAAGCCAGAGTGTGGCAGCACTCTAGCTTTTAAAAAAGAAACTACCCTTTAATAG
GAGGGTCCTCGTGTAGACACTTTTCCTTTACAGTAATGTAAATAGGATGAGTGTCTTTTTTTC

Structures

Toxin

• AlphaFold DB: A0A164X333

Antitoxin