Detailed information of TA system TA050274

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 131731..132431
• Replicon: chromosome
• Accession: NZ_CP010027
• Organism: Paraburkholderia fungorum strain ATCC BAA-463

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: A0A2T1AWY4
• Locus tag: OI25_RS25695
• Protein ID: WP_030100731.1
• Coordinates: 132135..132431 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: -
• Locus tag: OI25_RS25690
• Protein ID: WP_028197207.1
• Coordinates: 131731..132132 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OI25_RS25680	127174..130656	-	3483	WP_046570652.1	DEAD/DEAH box helicase	-
OI25_RS25685	130846..131625	-	780	WP_046570653.1	DeoR/GlpR family DNA-binding transcription regulator	-
OI25_RS25690	131731..132132	-	402	WP_028197207.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
OI25_RS25695	132135..132431	-	297	WP_030100731.1	type II toxin-antitoxin system MqsR family toxin	Toxin
OI25_RS25700	132599..135103	+	2505	WP_046570655.1	FAD-dependent oxidoreductase	-
OI25_RS25705	135100..135639	-	540	WP_046570668.1	cytochrome b	-
OI25_RS25710	135636..136727	-	1092	WP_046570670.1	catalase family peroxidase	-
OI25_RS25715	136835..137104	-	270	WP_028197212.1	DUF4148 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Zinc finger, MqsA-type (3-48)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 10739.53 Da
• Isoelectric Point: 7.8545

>T50274 WP_030100731.1 NZ_CP010027:c132431-132135 [Paraburkholderia fungorum]
MEKSTPHCKLAEVQSLARAGNIRITKSAVIGAAALGLGPAAIIETLLSLERGNFRKSMTTYADHRVWQDVYCAVTEAGMV
YLKLTVIDDVLVVSFKEW

Nucleotide

• Length: 297 bp

>T50274 NZ_CP010027:c132431-132135 [Paraburkholderia fungorum]
TTGGAAAAAAGTACGCCTCATTGCAAGCTGGCCGAGGTTCAAAGCCTGGCGCGTGCGGGGAACATCAGAATCACGAAATC
GGCCGTGATTGGAGCCGCGGCACTTGGCCTCGGACCCGCGGCAATCATCGAGACATTGCTGTCGCTCGAGCGCGGGAATT
TTCGAAAAAGCATGACCACGTACGCGGACCATCGGGTCTGGCAGGACGTCTACTGTGCCGTCACGGAAGCAGGCATGGTC
TATTTGAAATTGACGGTGATCGACGACGTTCTTGTCGTGTCATTCAAGGAGTGGTGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14738.86 Da
• Isoelectric Point: 5.0016

>AT50274 WP_028197207.1 NZ_CP010027:c132132-131731 [Paraburkholderia fungorum]
MKCPNCGAAELVRDTRNMRYVYKGETAVFEAVTGDYCPACDEAVLDIDEATRTGQMMLAFNKEVNASQVDPAFIAAVRKK
LDLDQREAAEIFGGGVNAFSRYENGKTRPPLALIKLLKVLDRHPELLEEVRAS

Nucleotide

• Length: 402 bp

>AT50274 NZ_CP010027:c132132-131731 [Paraburkholderia fungorum]
ATGAAATGCCCGAACTGCGGCGCGGCCGAACTGGTGCGCGATACGCGCAATATGCGCTATGTCTACAAGGGCGAGACGGC
TGTATTCGAAGCCGTCACGGGTGACTATTGTCCGGCGTGCGACGAGGCGGTGCTCGACATCGACGAAGCCACACGCACCG
GGCAAATGATGCTGGCTTTCAACAAAGAGGTGAATGCCTCGCAAGTGGATCCTGCCTTCATTGCCGCTGTGCGCAAGAAG
CTCGATCTGGACCAGCGCGAGGCAGCGGAGATTTTCGGCGGGGGGGTGAACGCCTTTTCGCGCTACGAAAATGGCAAGAC
CCGGCCGCCGCTCGCTCTAATCAAACTGTTGAAAGTGCTGGACCGGCATCCGGAGCTGCTGGAAGAAGTCAGGGCGAGTT
GA

Structures

Toxin

• AlphaFold DB: A0A2T1AWY4