Detailed information of TA system TA050265

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 3492315..3493009
• Replicon: chromosome
• Accession: NZ_CP010023
• Organism: Yersinia pestis str. Pestoides B

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: A0A0E1NW62
• Locus tag: CH60_RS17440
• Protein ID: WP_002214787.1
• Coordinates: 3492713..3493009 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q666X1
• Locus tag: CH60_RS17435
• Protein ID: WP_002209924.1
• Coordinates: 3492315..3492713 (-)
• Length: 133 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CH60_RS17400	3487505..3487870	+	366	WP_002209919.1	hypothetical protein	-
CH60_RS17405	3487883..3488119	+	237	WP_002214792.1	hypothetical protein	-
CH60_RS17410	3488125..3488457	+	333	WP_002214791.1	hypothetical protein	-
CH60_RS17415	3488639..3488839	+	201	WP_002209920.1	AlpA family transcriptional regulator	-
CH60_RS25015	3488853..3489005	-	153	WP_002209921.1	hypothetical protein	-
CH60_RS17425	3488998..3489324	-	327	WP_002209922.1	type II toxin-antitoxin system RelE/ParE family toxin	-
CH60_RS17430	3489624..3491915	+	2292	WP_002209923.1	toprim domain-containing protein	-
CH60_RS17435	3492315..3492713	-	399	WP_002209924.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
CH60_RS17440	3492713..3493009	-	297	WP_002214787.1	type II toxin-antitoxin system MqsR family toxin	Toxin
CH60_RS17445	3493173..3493535	-	363	WP_002209925.1	helix-turn-helix domain-containing protein	-
CH60_RS17450	3493598..3493858	-	261	WP_002214785.1	type II toxin-antitoxin system RelE/ParE family toxin	-
CH60_RS24895	3494456..3494650	+	195	WP_042659217.1	hypothetical protein	-
CH60_RS17465	3494706..3495920	-	1215	WP_002209929.1	tyrosine-type recombinase/integrase	-
CH60_RS17475	3496353..3497870	-	1518	WP_002209930.1	lysine--tRNA ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3482954..3494650	11696

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Cro/C1-type helix-turn-helix domain (75-128)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11319.12 Da
• Isoelectric Point: 7.8810

>T50265 WP_002214787.1 NZ_CP010023:c3493009-3492713 [Yersinia pestis str. Pestoides B]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLNVSFKEI

Nucleotide

• Length: 297 bp

>T50265 NZ_CP010023:c3493009-3492713 [Yersinia pestis str. Pestoides B]
ATGGAGAAACGGACTCCGCATACTCGTTTATTAAAAGTAAAAGAATTGGTATTGAAGGGGAATATTAAAACGACACGAAC
TGCCAGAGATGGGGCTGAGGAACTGGGACTGAGTTTTAGAGATATGTGTGATGCAGTTTCCGAACTGATTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACCATTTGGCAGGATGTTTACCGTCCTATGCTTTCTTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGAATGTCTCGTTTAAGGAGATTTAA

Antitoxin

Protein

• Length: 133 a.a.
• Molecular weight: 14657.17 Da
• Isoelectric Point: 8.4923

>AT50265 WP_002209924.1 NZ_CP010023:c3492713-3492315 [Yersinia pestis str. Pestoides B]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Nucleotide

• Length: 399 bp

>AT50265 NZ_CP010023:c3492713-3492315 [Yersinia pestis str. Pestoides B]
ATGATGAAATGTCCAGTTTGTGGCGGTGTAGAATTAATCCACGAAGCGCGTGACGTTCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGGCAACATTGCCCGGCATGCGGTGAAACAGTCATGACCGAAGCCGAGTCCGATGTCT
ATGCAGCAAAAACAATGCTTTTGCGAAAAATGGTCAATACAGAATCGATTGCCCCCGCATATATTGTGCAGATCCGAAAA
AAGTTGGGCCTAAACCAGCGGGAAGCCAGTGAGATTTTTGGTGGTGGGGTTAATGCATTTTCGCGTTACGAAAAAGGTAA
GGCTTTGCCACATCCATCAACGATAAAACTGTTGCAAGTGCTTGATAAACACCCGGAGTTATTGAATGAAATTAGGTAG

Structures

Toxin

• AlphaFold DB: A0A0E1NW62

Antitoxin

• AlphaFold DB: Q666X1