Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1266406..1267100 Replicon chromosome
Accession NZ_CP009991
Organism Yersinia pestis strain Nicholisk 41

Toxin (Protein)


Gene name mqsR Uniprot ID A0A0E1NW62
Locus tag CH63_RS06995 Protein ID WP_002214787.1
Coordinates 1266804..1267100 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q666X1
Locus tag CH63_RS06990 Protein ID WP_002209924.1
Coordinates 1266406..1266804 (-) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH63_RS06955 1261596..1261961 + 366 WP_002209919.1 hypothetical protein -
CH63_RS06960 1261974..1262210 + 237 WP_002214792.1 hypothetical protein -
CH63_RS06965 1262216..1262548 + 333 WP_002214791.1 hypothetical protein -
CH63_RS06970 1262730..1262930 + 201 WP_002209920.1 AlpA family transcriptional regulator -
CH63_RS24815 1262944..1263096 - 153 WP_002209921.1 hypothetical protein -
CH63_RS06980 1263089..1263415 - 327 WP_002209922.1 type II toxin-antitoxin system RelE/ParE family toxin -
CH63_RS06985 1263715..1266006 + 2292 WP_002209923.1 toprim domain-containing protein -
CH63_RS06990 1266406..1266804 - 399 WP_002209924.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
CH63_RS06995 1266804..1267100 - 297 WP_002214787.1 type II toxin-antitoxin system MqsR family toxin Toxin
CH63_RS07000 1267264..1267626 - 363 WP_002209925.1 helix-turn-helix domain-containing protein -
CH63_RS07005 1267689..1267949 - 261 WP_002214785.1 type II toxin-antitoxin system RelE/ParE family toxin -
CH63_RS07015 1268547..1268732 + 186 WP_002209928.1 hypothetical protein -
CH63_RS07020 1268814..1270028 - 1215 WP_002209929.1 tyrosine-type recombinase/integrase -
CH63_RS07030 1270461..1271978 - 1518 WP_002209930.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11319.12 Da        Isoelectric Point: 7.8810

>T50213 WP_002214787.1 NZ_CP009991:c1267100-1266804 [Yersinia pestis]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLNVSFKEI

Download         Length: 297 bp

>T50213 NZ_CP009991:c1267100-1266804 [Yersinia pestis]
ATGGAGAAACGGACTCCGCATACTCGTTTATTAAAAGTAAAAGAATTGGTATTGAAGGGGAATATTAAAACGACACGAAC
TGCCAGAGATGGGGCTGAGGAACTGGGACTGAGTTTTAGAGATATGTGTGATGCAGTTTCCGAACTGATTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACCATTTGGCAGGATGTTTACCGTCCTATGCTTTCTTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGAATGTCTCGTTTAAGGAGATTTAA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14657.17 Da        Isoelectric Point: 8.4923

>AT50213 WP_002209924.1 NZ_CP009991:c1266804-1266406 [Yersinia pestis]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Download         Length: 399 bp

>AT50213 NZ_CP009991:c1266804-1266406 [Yersinia pestis]
ATGATGAAATGTCCAGTTTGTGGCGGTGTAGAATTAATCCACGAAGCGCGTGACGTTCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGGCAACATTGCCCGGCATGCGGTGAAACAGTCATGACCGAAGCCGAGTCCGATGTCT
ATGCAGCAAAAACAATGCTTTTGCGAAAAATGGTCAATACAGAATCGATTGCCCCCGCATATATTGTGCAGATCCGAAAA
AAGTTGGGCCTAAACCAGCGGGAAGCCAGTGAGATTTTTGGTGGTGGGGTTAATGCATTTTCGCGTTACGAAAAAGGTAA
GGCTTTGCCACATCCATCAACGATAAAACTGTTGCAAGTGCTTGATAAACACCCGGAGTTATTGAATGAAATTAGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1NW62

Antitoxin

Source ID Structure
AlphaFold DB Q666X1

References