Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1859570..1860264 Replicon chromosome
Accession NZ_CP009973
Organism Yersinia pestis CO92

Toxin (Protein)


Gene name mqsR Uniprot ID A0A0E1NW62
Locus tag AK38_RS09610 Protein ID WP_002214787.1
Coordinates 1859570..1859866 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q666X1
Locus tag AK38_RS09615 Protein ID WP_002209924.1
Coordinates 1859866..1860264 (+) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AK38_RS09575 1854692..1856209 + 1518 WP_002209930.1 lysine--tRNA ligase -
AK38_RS09585 1856642..1857856 + 1215 WP_002209929.1 tyrosine-type recombinase/integrase -
AK38_RS09590 1857938..1858123 - 186 WP_002209928.1 hypothetical protein -
AK38_RS09600 1858721..1858981 + 261 WP_002214785.1 type II toxin-antitoxin system RelE/ParE family toxin -
AK38_RS09605 1859044..1859406 + 363 WP_002209925.1 helix-turn-helix domain-containing protein -
AK38_RS09610 1859570..1859866 + 297 WP_002214787.1 type II toxin-antitoxin system MqsR family toxin Toxin
AK38_RS09615 1859866..1860264 + 399 WP_002209924.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
AK38_RS09620 1860664..1862955 - 2292 WP_002209923.1 toprim domain-containing protein -
AK38_RS09625 1863255..1863581 + 327 WP_002209922.1 type II toxin-antitoxin system RelE/ParE family toxin -
AK38_RS24835 1863574..1863726 + 153 WP_002209921.1 hypothetical protein -
AK38_RS09635 1863740..1863940 - 201 WP_002209920.1 AlpA family transcriptional regulator -
AK38_RS09640 1864122..1864454 - 333 WP_002214791.1 hypothetical protein -
AK38_RS09645 1864460..1864696 - 237 WP_002214792.1 hypothetical protein -
AK38_RS09650 1864709..1865074 - 366 WP_002209919.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11319.12 Da        Isoelectric Point: 7.8810

>T50195 WP_002214787.1 NZ_CP009973:1859570-1859866 [Yersinia pestis CO92]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLNVSFKEI

Download         Length: 297 bp

>T50195 NZ_CP009973:1859570-1859866 [Yersinia pestis CO92]
ATGGAGAAACGGACTCCGCATACTCGTTTATTAAAAGTAAAAGAATTGGTATTGAAGGGGAATATTAAAACGACACGAAC
TGCCAGAGATGGGGCTGAGGAACTGGGACTGAGTTTTAGAGATATGTGTGATGCAGTTTCCGAACTGATTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACCATTTGGCAGGATGTTTACCGTCCTATGCTTTCTTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGAATGTCTCGTTTAAGGAGATTTAA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14657.17 Da        Isoelectric Point: 8.4923

>AT50195 WP_002209924.1 NZ_CP009973:1859866-1860264 [Yersinia pestis CO92]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Download         Length: 399 bp

>AT50195 NZ_CP009973:1859866-1860264 [Yersinia pestis CO92]
ATGATGAAATGTCCAGTTTGTGGCGGTGTAGAATTAATCCACGAAGCGCGTGACGTTCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGGCAACATTGCCCGGCATGCGGTGAAACAGTCATGACCGAAGCCGAGTCCGATGTCT
ATGCAGCAAAAACAATGCTTTTGCGAAAAATGGTCAATACAGAATCGATTGCCCCCGCATATATTGTGCAGATCCGAAAA
AAGTTGGGCCTAAACCAGCGGGAAGCCAGTGAGATTTTTGGTGGTGGGGTTAATGCATTTTCGCGTTACGAAAAAGGTAA
GGCTTTGCCACATCCATCAACGATAAAACTGTTGCAAGTGCTTGATAAACACCCGGAGTTATTGAATGAAATTAGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1NW62

Antitoxin

Source ID Structure
AlphaFold DB Q666X1

References