Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 585545..586239 Replicon chromosome
Accession NZ_CP009935
Organism Yersinia pestis Angola

Toxin (Protein)


Gene name mqsR Uniprot ID A0A0E1NW62
Locus tag CH56_RS03370 Protein ID WP_002214787.1
Coordinates 585545..585841 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q666X1
Locus tag CH56_RS03375 Protein ID WP_002209924.1
Coordinates 585841..586239 (+) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH56_RS03335 580667..582184 + 1518 WP_002209930.1 lysine--tRNA ligase -
CH56_RS03345 582617..583831 + 1215 WP_002209929.1 tyrosine-type recombinase/integrase -
CH56_RS03350 583913..584098 - 186 WP_002209928.1 hypothetical protein -
CH56_RS03360 584696..584956 + 261 WP_002214785.1 type II toxin-antitoxin system RelE/ParE family toxin -
CH56_RS03365 585019..585381 + 363 WP_002209925.1 helix-turn-helix domain-containing protein -
CH56_RS03370 585545..585841 + 297 WP_002214787.1 type II toxin-antitoxin system MqsR family toxin Toxin
CH56_RS03375 585841..586239 + 399 WP_002209924.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
CH56_RS03380 586639..588930 - 2292 WP_002209923.1 toprim domain-containing protein -
CH56_RS03385 589230..589556 + 327 WP_002209922.1 type II toxin-antitoxin system RelE/ParE family toxin -
CH56_RS25165 589549..589701 + 153 WP_002209921.1 hypothetical protein -
CH56_RS03395 589715..589915 - 201 WP_002209920.1 AlpA family transcriptional regulator -
CH56_RS03400 590097..590429 - 333 WP_002214791.1 hypothetical protein -
CH56_RS03405 590435..590671 - 237 WP_002214792.1 hypothetical protein -
CH56_RS03410 590684..591049 - 366 WP_002209919.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11319.12 Da        Isoelectric Point: 7.8810

>T50161 WP_002214787.1 NZ_CP009935:585545-585841 [Yersinia pestis Angola]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLNVSFKEI

Download         Length: 297 bp

>T50161 NZ_CP009935:585545-585841 [Yersinia pestis Angola]
ATGGAGAAACGGACTCCGCATACTCGTTTATTAAAAGTAAAAGAATTGGTATTGAAGGGGAATATTAAAACGACACGAAC
TGCCAGAGATGGGGCTGAGGAACTGGGACTGAGTTTTAGAGATATGTGTGATGCAGTTTCCGAACTGATTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACCATTTGGCAGGATGTTTACCGTCCTATGCTTTCTTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGAATGTCTCGTTTAAGGAGATTTAA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14657.17 Da        Isoelectric Point: 8.4923

>AT50161 WP_002209924.1 NZ_CP009935:585841-586239 [Yersinia pestis Angola]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Download         Length: 399 bp

>AT50161 NZ_CP009935:585841-586239 [Yersinia pestis Angola]
ATGATGAAATGTCCAGTTTGTGGCGGTGTAGAATTAATCCACGAAGCGCGTGACGTTCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGGCAACATTGCCCGGCATGCGGTGAAACAGTCATGACCGAAGCCGAGTCCGATGTCT
ATGCAGCAAAAACAATGCTTTTGCGAAAAATGGTCAATACAGAATCGATTGCCCCCGCATATATTGTGCAGATCCGAAAA
AAGTTGGGCCTAAACCAGCGGGAAGCCAGTGAGATTTTTGGTGGTGGGGTTAATGCATTTTCGCGTTACGAAAAAGGTAA
GGCTTTGCCACATCCATCAACGATAAAACTGTTGCAAGTGCTTGATAAACACCCGGAGTTATTGAATGAAATTAGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1NW62

Antitoxin

Source ID Structure
AlphaFold DB Q666X1

References