Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3547679..3548373 Replicon chromosome
Accession NZ_CP009906
Organism Yersinia pestis Antiqua

Toxin (Protein)


Gene name mqsR Uniprot ID A0A0E1NW62
Locus tag CH58_RS17610 Protein ID WP_002214787.1
Coordinates 3547679..3547975 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q666X1
Locus tag CH58_RS17615 Protein ID WP_002209924.1
Coordinates 3547975..3548373 (+) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH58_RS17570 3542792..3542983 + 192 Protein_3088 DUF4102 domain-containing protein -
CH58_RS17575 3543049..3543828 - 780 WP_001297096.1 IS21-like element IS100kyp family helper ATPase IstB -
CH58_RS17580 3543828..3544850 - 1023 WP_000255944.1 IS21-like element IS100 family transposase -
CH58_RS17585 3544907..3545965 + 1059 WP_002220106.1 tyrosine-type recombinase/integrase -
CH58_RS17590 3546047..3546232 - 186 WP_002209928.1 hypothetical protein -
CH58_RS17600 3546830..3547090 + 261 WP_002214785.1 type II toxin-antitoxin system RelE/ParE family toxin -
CH58_RS17605 3547153..3547515 + 363 WP_002209925.1 helix-turn-helix domain-containing protein -
CH58_RS17610 3547679..3547975 + 297 WP_002214787.1 type II toxin-antitoxin system MqsR family toxin Toxin
CH58_RS17615 3547975..3548373 + 399 WP_002209924.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
CH58_RS17620 3548773..3551064 - 2292 WP_002209923.1 toprim domain-containing protein -
CH58_RS17625 3551364..3551690 + 327 WP_002209922.1 type II toxin-antitoxin system RelE/ParE family toxin -
CH58_RS26205 3551683..3551835 + 153 WP_002209921.1 hypothetical protein -
CH58_RS17635 3551849..3552049 - 201 WP_002209920.1 AlpA family transcriptional regulator -
CH58_RS17640 3552231..3552563 - 333 WP_002214791.1 hypothetical protein -
CH58_RS17645 3552569..3552805 - 237 WP_002214792.1 hypothetical protein -
CH58_RS17650 3552818..3553183 - 366 WP_002209919.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11319.12 Da        Isoelectric Point: 7.8810

>T50140 WP_002214787.1 NZ_CP009906:3547679-3547975 [Yersinia pestis Antiqua]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLNVSFKEI

Download         Length: 297 bp

>T50140 NZ_CP009906:3547679-3547975 [Yersinia pestis Antiqua]
ATGGAGAAACGGACTCCGCATACTCGTTTATTAAAAGTAAAAGAATTGGTATTGAAGGGGAATATTAAAACGACACGAAC
TGCCAGAGATGGGGCTGAGGAACTGGGACTGAGTTTTAGAGATATGTGTGATGCAGTTTCCGAACTGATTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACCATTTGGCAGGATGTTTACCGTCCTATGCTTTCTTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGAATGTCTCGTTTAAGGAGATTTAA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14657.17 Da        Isoelectric Point: 8.4923

>AT50140 WP_002209924.1 NZ_CP009906:3547975-3548373 [Yersinia pestis Antiqua]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Download         Length: 399 bp

>AT50140 NZ_CP009906:3547975-3548373 [Yersinia pestis Antiqua]
ATGATGAAATGTCCAGTTTGTGGCGGTGTAGAATTAATCCACGAAGCGCGTGACGTTCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGGCAACATTGCCCGGCATGCGGTGAAACAGTCATGACCGAAGCCGAGTCCGATGTCT
ATGCAGCAAAAACAATGCTTTTGCGAAAAATGGTCAATACAGAATCGATTGCCCCCGCATATATTGTGCAGATCCGAAAA
AAGTTGGGCCTAAACCAGCGGGAAGCCAGTGAGATTTTTGGTGGTGGGGTTAATGCATTTTCGCGTTACGAAAAAGGTAA
GGCTTTGCCACATCCATCAACGATAAAACTGTTGCAAGTGCTTGATAAACACCCGGAGTTATTGAATGAAATTAGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1NW62

Antitoxin

Source ID Structure
AlphaFold DB Q666X1

References